Ren Juan, Song Liping, Dang Qiang, Zhang Xiaozhi, Jiang Shi-Wen, Zhang Guanjun, Wang Ning, Liu Zi, Wang Jiansheng, Hwa Yi Lisa, Li Zongfang, Zhao Xinhan, Liu Yuan
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Medical school of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, PR China.
Head Neck Oncol. 2010 Mar 31;2:7. doi: 10.1186/1758-3284-2-7.
We present a case of adenomyoepithlioma (AME) arising from the tonsil. AME is an uncommon tumor that typically arises in breast, but rarely found in salivary glands, lung, and skin. Its biological features have not been thoroughly characterized. Here we describe a primary AME originating from the tonsil. The pathologic changes were characterized by hypercellularity, the dominance of both epithelial and myoepithelial cells. Malignancy was evidenced by the presence of a high mitotic rate and invasive growth. The epithelial cells express high levels of cytokeratin and epithelial membrane antigen (EMA). The myoepithelial cells show positive staining for calponin, p63, vimentin, and S-100. A thorough review of the literature indicates that this is likely the first reported case of AME from the tonsil. Following descriptions of the diagnosis, treatment, and prognosis of this specific case, pathologic and clinical characteristics of AME from other tissues are also compiled and discussed.
我们报告一例起源于扁桃体的腺肌上皮瘤（AME）。AME是一种罕见肿瘤，通常发生于乳腺，但在唾液腺、肺和皮肤中很少见。其生物学特性尚未得到充分表征。在此，我们描述一例起源于扁桃体的原发性AME。病理变化的特征为细胞增多，上皮细胞和肌上皮细胞均占主导。高有丝分裂率和浸润性生长证明存在恶性。上皮细胞高水平表达细胞角蛋白和上皮膜抗原（EMA）。肌上皮细胞对钙调蛋白、p63、波形蛋白和S-100呈阳性染色。对文献的全面回顾表明，这可能是首例报道的来自扁桃体的AME病例。在描述该特定病例的诊断、治疗和预后之后，还汇总并讨论了来自其他组织的AME的病理和临床特征。
