Lee Jimmy K F
Department of Paediatrics, Kuala Terengganu Hospital, Jalan Sultan Mahmud, Kuala Terengganu, Malaysia.
J Paediatr Child Health. 2008 Jan;44(1-2):62-6. doi: 10.1111/j.1440-1754.2007.01173.x. Epub 2007 Jul 19.
An outbreak of Burkholderia cepacia septicaemia occurred in our neonatal unit over a 9-week period in 2001, affecting 23 babies and two died. A second outbreak lasting 8 days occurred a year later, affecting five babies.
Neonatal Intensive Care Unit, Kuala Terengganu Hospital.
To review the patient characteristics and the risk factors for septicaemia in the first outbreak.
Retrospective review of records and in the first outbreak a case-control analysis with 23 matched controls for risk factors for septicaemia.
In the first outbreak, median birthweight was 1670 g (range 860-3760) and median gestational age was 32 weeks (range 27-41). There were 32 episodes of septicaemia, and five and two patients had two and three episodes, respectively. The mortality rate was 6.3% per septicaemic episode. Multiple logistic regression showed the presence of a prior long line was associated with first septicaemic episode (OR 7.07, 95% CI 1.37-36.47 with P = 0.019) but not prior assisted ventilation. The organism was isolated from the water of an oxygen humidifier in the delivery room, three ventilator water traps and one humidifier water trap in the neonatal unit. In the second outbreak, six episodes of septicaemia occurred in five neonates with median birthweight 2060 g and median gestational age 32.5 weeks. The organism was isolated from two ventilator water traps.
These two outbreaks of Burkholderia cepacia subsided with general infection control measures. The sources of these two outbreaks were not identified.
2001年，我们新生儿病房在9周内爆发了洋葱伯克霍尔德菌败血症，23名婴儿受影响，2名死亡。一年后发生了持续8天的第二次爆发，5名婴儿受影响。
瓜拉丁加奴医院新生儿重症监护病房。
回顾首次爆发中败血症患者的特征及危险因素。
回顾病历，在首次爆发中对23例败血症危险因素进行病例对照分析。
在首次爆发中，出生体重中位数为1670克（范围860 - 3760克），胎龄中位数为32周（范围27 - 41周）。共发生32次败血症发作，分别有5名和2名患者发作2次和3次。每次败血症发作的死亡率为6.3%。多因素logistic回归显示，先前存在长期置管与首次败血症发作相关（比值比7.07，95%可信区间1.37 - 36.47，P = 0.019），但与先前的辅助通气无关。该病菌从产房的一个氧气加湿器、新生儿病房的三个呼吸机集水杯和一个加湿器集水杯的水中分离出来。在第二次爆发中，5名新生儿发生6次败血症发作，出生体重中位数为2060克，胎龄中位数为32.5周。该病菌从两个呼吸机集水杯中分离出来。
这两次洋葱伯克霍尔德菌爆发通过一般感染控制措施得到平息。这两次爆发的源头未查明。
