胸腺基质淋巴细胞生成素参与早期胸腺细胞祖细胞的扩增。
TSLP is involved in expansion of early thymocyte progenitors.
作者信息
Jiang Qi, Coffield V McNeil, Kondo Motonari, Su Lishan
机构信息
Lineberger Comprehensive Cancer Center, School of Medicine, UNC at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
BMC Immunol. 2007 Jul 18;8:11. doi: 10.1186/1471-2172-8-11.
BACKGROUND
Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
RESULTS
We report here that TSLP, independently or in combination with IL-7, enhances thymopoiesis in the murine fetal thymic organ culture (FTOC) model. Furthermore, TSLP preferentially increases the number and proliferation of the (DN1 and DN2) pro-T progenitor cells, and FTOC lobes from TSLP receptor-null mice show a decreased number of these cells. Finally, DN1-DN2 cells expanded with TSLP in vitro are functional T progenitors that are able to differentiate into mature T cells in fetal or adult thymus organs.
CONCLUSION
Together, these data suggest that TSLP plays an important role in expansion of thymocyte progenitors and may be of value for expanding T progenitor cells in vitro.
背景
胸腺基质衍生的淋巴细胞生成素（TSLP）在胸腺中优先且高表达，但其在T细胞发育中的功能尚不清楚。
结果
我们在此报告，TSLP单独或与白细胞介素-7联合使用，可增强小鼠胎儿胸腺器官培养（FTOC）模型中的胸腺生成。此外，TSLP优先增加（DN1和DN2）前T祖细胞的数量和增殖，来自TSLP受体缺失小鼠的FTOC叶显示这些细胞数量减少。最后，在体外与TSLP一起扩增的DN1-DN2细胞是功能性T祖细胞，能够在胎儿或成年胸腺器官中分化为成熟T细胞。
结论
总之，这些数据表明TSLP在胸腺细胞祖细胞的扩增中起重要作用，并且可能对于在体外扩增T祖细胞具有价值。
Zotero 插件