胸腺基质淋巴细胞生成素参与早期胸腺细胞祖细胞的扩增。

TSLP is involved in expansion of early thymocyte progenitors.

作者信息

Jiang Qi, Coffield V McNeil, Kondo Motonari, Su Lishan

机构信息

Lineberger Comprehensive Cancer Center, School of Medicine, UNC at Chapel Hill, Chapel Hill, NC 27599, USA.

出版信息

BMC Immunol. 2007 Jul 18;8:11. doi: 10.1186/1471-2172-8-11.

BACKGROUND

Thymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.

RESULTS

We report here that TSLP, independently or in combination with IL-7, enhances thymopoiesis in the murine fetal thymic organ culture (FTOC) model. Furthermore, TSLP preferentially increases the number and proliferation of the (DN1 and DN2) pro-T progenitor cells, and FTOC lobes from TSLP receptor-null mice show a decreased number of these cells. Finally, DN1-DN2 cells expanded with TSLP in vitro are functional T progenitors that are able to differentiate into mature T cells in fetal or adult thymus organs.

CONCLUSION

Together, these data suggest that TSLP plays an important role in expansion of thymocyte progenitors and may be of value for expanding T progenitor cells in vitro.

背景

胸腺基质衍生的淋巴细胞生成素（TSLP）在胸腺中优先且高表达，但其在T细胞发育中的功能尚不清楚。

结果

我们在此报告，TSLP单独或与白细胞介素-7联合使用，可增强小鼠胎儿胸腺器官培养（FTOC）模型中的胸腺生成。此外，TSLP优先增加（DN1和DN2）前T祖细胞的数量和增殖，来自TSLP受体缺失小鼠的FTOC叶显示这些细胞数量减少。最后，在体外与TSLP一起扩增的DN1-DN2细胞是功能性T祖细胞，能够在胎儿或成年胸腺器官中分化为成熟T细胞。