先天淋巴细胞中的白细胞介素-7 受体 α：不仅仅是一个标志物。
Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker.
机构信息
Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada.
Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada.
出版信息
Front Immunol. 2019 Dec 11;10:2897. doi: 10.3389/fimmu.2019.02897. eCollection 2019.
Innate lymphoid cells (ILCs) are a group of immune cells that are important for defense against pathogens, tissue repair, and lymphoid organogenesis. They share similar characteristics with various subsets of helper T cells but lack specific antigen receptors. Interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP) are cytokines that engage the IL-7Rα and have major roles in dictating the fate of ILCs. Recent advances in the field have revealed transcriptional programs associated with ILC development and function. In this article, we will review recent studies of the role of IL-7 and TSLP in ILC development and function during infection and inflammation.
先天淋巴细胞（ILC）是一组重要的免疫细胞，有助于抵御病原体、组织修复和淋巴器官发生。它们与各种辅助性 T 细胞亚群具有相似的特征，但缺乏特定的抗原受体。白细胞介素 7（IL-7）和胸腺基质淋巴细胞生成素（TSLP）是细胞因子，与 IL-7Rα 结合，在决定 ILC 命运方面发挥主要作用。该领域的最新进展揭示了与 ILC 发育和功能相关的转录程序。在本文中，我们将回顾最近关于 IL-7 和 TSLP 在感染和炎症期间对 ILC 发育和功能作用的研究。
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