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Part of the phospho group of pyridoxal phosphate may titrate over the pH range 5-8 in aspartate aminotransferase.

作者信息

Dixon H B

出版信息

Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):832-3. doi: 10.1042/bj2800832.

DOI:10.1042/bj2800832
PMID:1764047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1130534/
Abstract
摘要

相似文献

1
Part of the phospho group of pyridoxal phosphate may titrate over the pH range 5-8 in aspartate aminotransferase.在天冬氨酸转氨酶中，磷酸吡哆醛的部分磷酸基团可能在pH值5 - 8的范围内被滴定。
Biochem J. 1991 Dec 15;280 ( Pt 3)(Pt 3):832-3. doi: 10.1042/bj2800832.
2
Transient-state kinetics of the reaction of aspartate aminotransferase with aspartate at low pH reveals dual routes in the enzyme-substrate association process.低pH条件下天冬氨酸转氨酶与天冬氨酸反应的瞬态动力学揭示了酶-底物结合过程中的双重途径。
Biochemistry. 1997 Nov 4;36(44):13558-69. doi: 10.1021/bi971638z.
3
NMR observation of exchangeable protons of pyridoxal phosphate and histidine residues in cytosolic aspartate aminotransferase.
J Biol Chem. 1991 Sep 15;266(26):17222-9.
4
The imine-pyridine torsion of the pyridoxal 5'-phosphate Schiff base of aspartate aminotransferase lowers its pKa in the unliganded enzyme and is crucial for the successive increase in the pKa during catalysis.天冬氨酸转氨酶的磷酸吡哆醛席夫碱的亚胺-吡啶扭转降低了其在无配体酶中的pKa，并且对于催化过程中pKa的连续增加至关重要。
Biochemistry. 1998 Oct 27;37(43):15076-85. doi: 10.1021/bi981517e.
5
[RADIOCHROMATOGRAPHY STUDY ON STABILITY OF THE (7-C14) BENZOYLHYDRAZONE OF PHOSPHO-5'-PYRIDOXAL IN THE PRESENCE OF PYRIDOXAL ENZYMES].
Bull Soc Chim Biol (Paris). 1965;47:481-91.
6
NMR studies of protonation and hydrogen bond states of internal aldimines of pyridoxal 5'-phosphate acid-base in alanine racemase, aspartate aminotransferase, and poly-L-lysine.NMR 研究丙氨酸消旋酶、天冬氨酸转氨酶和聚-L-赖氨酸中吡哆醛 5′-磷酸酸碱内醛亚胺的质子化和氢键状态。
J Am Chem Soc. 2013 Dec 4;135(48):18160-75. doi: 10.1021/ja408988z. Epub 2013 Nov 21.
7
Purification and characterization of aspartate aminotransferase from the halophile archaebacterium Haloferax mediterranei.嗜盐古细菌地中海富盐菌中天冬氨酸转氨酶的纯化及特性分析
Biochem J. 1991 Aug 15;278 ( Pt 1)(Pt 1):149-54. doi: 10.1042/bj2780149.
8
[SPECTRAL STUDY OF THE BINDING OF PYRIDOXAL-5'-PHOSPHATE ISONICOTINOYLHYDRAZONE TO ASPARTIC-GLUTAMIC APO-TRANSAMINASE].[吡哆醛-5'-磷酸异烟酰腙与天冬氨酸-谷氨酸脱辅基转氨酶结合的光谱研究]
C R Hebd Seances Acad Sci. 1964 Feb 10;258:1911-3.
9
X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase.
J Mol Biol. 1992 May 20;225(2):495-517. doi: 10.1016/0022-2836(92)90935-d.
10
Importance of pyridoxal-5'-phosphate addition to the assay medium for the measurement of catalytic concentrations of plasma aspartate and alanine aminotransferases in patients undergoing antineoplastic chemotherapy.在接受抗肿瘤化疗的患者中，向测定介质中添加磷酸吡哆醛对于测定血浆天冬氨酸和丙氨酸转氨酶催化浓度的重要性。
Eur J Clin Chem Clin Biochem. 1996 Jun;34(6):507-10.

本文引用的文献

1
31P nuclear magnetic resonance of mitochondrial aspartate aminotransferase. The effects of solution pH and ligand binding.线粒体天冬氨酸氨基转移酶的31P核磁共振。溶液pH值和配体结合的影响。
J Biol Chem. 1982 Aug 10;257(15):8872-8.
2
Spectra of 3-hydroxypyridines. Band-shape analysis and evaluation of tautomeric equilibria.3-羟基吡啶的光谱。能带形状分析与互变异构平衡评估。
Biochemistry. 1973 Dec 18;12(26):5377-92. doi: 10.1021/bi00750a022.
3
Negatively co-operative ligand binding.负协同配体结合
Biochem J. 1973 Aug;133(4):837-42. doi: 10.1042/bj1330837.
4
Ionization state of the coenzyme 5'-phosphate ester in cytosolic aspartate aminotransferase. A Fourier transform infrared spectroscopic study.
Biochemistry. 1986 May 20;25(10):2915-20. doi: 10.1021/bi00358a027.
5
Phosphorus-31 nuclear magnetic resonance of aspartate aminotransferase from chicken heart cytosol.鸡心脏胞质溶胶中天冬氨酸转氨酶的磷-31核磁共振
Biochim Biophys Acta. 1987 Sep 24;915(2):299-304. doi: 10.1016/0167-4838(87)90313-x.
6
[31P-NMR spectra of aspartate aminotransferase from cytosol of the chicken heart].[鸡心脏细胞溶质中天冬氨酸转氨酶的31P-核磁共振谱]
Bioorg Khim. 1987 Apr;13(4):550-1.
7
Evidence that 31P NMR is a sensitive indicator of small conformational changes in the coenzyme of aspartate aminotransferase.31P核磁共振是天冬氨酸转氨酶辅酶中微小构象变化的灵敏指标的证据。
Eur J Biochem. 1989 Nov 20;185(3):525-31. doi: 10.1111/j.1432-1033.1989.tb15145.x.
8
The ionization states of the 5'-phosphate group in the various coenzyme forms bound to mitochondrial aspartate aminotransferase.与线粒体天冬氨酸氨基转移酶结合的各种辅酶形式中5'-磷酸基团的电离状态。
Arch Biochem Biophys. 1991 Apr;286(1):38-45. doi: 10.1016/0003-9861(91)90006-5.
9
The origin of multiply sigmoid curves of pH-dependence. The partitioning of groups among titration pK values.pH依赖性多重S形曲线的起源。各基团在滴定pK值间的分配。
Biochem J. 1991 Aug 15;278 ( Pt 1)(Pt 1):279-84. doi: 10.1042/bj2780279.
10
The unreliability of estimates of group dissociation constants.基团解离常数估计值的不可靠性。
Biochem J. 1976 Mar 1;153(3):627-9. doi: 10.1042/bj1530627.