Frith C H, Dooley K
J Natl Cancer Inst. 1976 Mar;56(3):679-82. doi: 10.1093/jnci/56.3.679.
The administration of benzidine dihydrochloride in water to mice for up to 39 weeks resulted in hemosiderosis of the spleen, focal vacuolization of the transitional epithelium of the urinary bladder, and chronic inflammation and cytologic and neoplastic changes in the liver. Basophilic and acidophilic cytologic foci appeared in the liver as two distinct entities and both appeared preneoplastic. Benign and malignant liver tumors were also seen. Both types of cytologic changes and malignant liver tumors were more common in the female than male mouse.
给小鼠在水中投喂二盐酸联苯胺长达39周，导致脾脏出现含铁血黄素沉着症、膀胱移行上皮出现局灶性空泡化，以及肝脏出现慢性炎症、细胞学变化和肿瘤变化。嗜碱性和嗜酸性细胞学病灶在肝脏中表现为两种不同的实体，且两者均表现为癌前病变。还观察到了良性和恶性肝肿瘤。两种类型的细胞学变化和恶性肝肿瘤在雌性小鼠中比雄性小鼠中更常见。
