Miyakawa M, Yoshida O
Gan. 1980 Apr;71(2):265-8.
This study was undertaken to evaluate the carcinogenic effect of benzidine on the urinary bladder of mice, and the effect of DL-tryptophan on the induction of bladder cancer. Benzidine plus DL-tryptophan or benzidine alone mixed with a commercial basal diet was fed to groups of ICR strain female mice for 20 weeks, after a glass bead had been inserted into the bladder. Control mice were fed the basal diet throughout the experimental period. All the surviving mice were killed 63 weeks after start of the study. Benzidine administered with or without DL-tryptophan did not induce tumors of the urinary bladder in these mice. Hepatomas developed in 34 of 41 mice (82.9%) fed benzidine and in 24 of 51 mice (47.1%) fed benzidine with tryptophan. DL-Tryptophan counteracted the effect of benzidine and significantly reduced the development of hepatomas.
本研究旨在评估联苯胺对小鼠膀胱的致癌作用，以及DL-色氨酸对膀胱癌诱导的影响。在将玻璃珠插入膀胱后，将联苯胺加DL-色氨酸或单独的联苯胺与市售基础饲料混合，喂食ICR品系雌性小鼠组20周。对照小鼠在整个实验期间喂食基础饲料。在研究开始63周后，处死所有存活的小鼠。无论是否添加DL-色氨酸，联苯胺均未在这些小鼠中诱发膀胱肿瘤。在喂食联苯胺的41只小鼠中有34只（82.9%）发生肝癌，在喂食联苯胺加色氨酸的51只小鼠中有24只（47.1%）发生肝癌。DL-色氨酸抵消了联苯胺的作用，并显著降低了肝癌的发生。
