Sebenik Matjaz, Yan Zhijije, Khalbuss Walid E, Mittal Khush
North Broward Medical Center, Deerfield Beach, FL 33064, USA.
Hum Pathol. 2007 Aug;38(8):1282-8. doi: 10.1016/j.humpath.2007.03.008.
The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components.
患者为一名57岁的白人女性，出现一个3.0×2.0厘米的部分溃疡的阴道息肉。组织学检查显示为恶性混合性苗勒管肿瘤，由浸润性鳞状细胞癌和更深层的未分化多形性肉瘤组成。浸润性癌上方有高级别阴道上皮内瘤变（VaIN III），其中含有挖空细胞异型性。原位杂交在癌和肉瘤成分中均检测到高危型人乳头瘤病毒DNA。
