阴道恶性苗勒管混合瘤：病例报告并文献复习、免疫组化研究及人乳头瘤病毒评估

Malignant mixed mullerian tumor of the vagina: case report with review of the literature, immunohistochemical study, and evaluation for human papilloma virus.

作者信息

Sebenik Matjaz, Yan Zhijije, Khalbuss Walid E, Mittal Khush

机构信息

North Broward Medical Center, Deerfield Beach, FL 33064, USA.

出版信息

Hum Pathol. 2007 Aug;38(8):1282-8. doi: 10.1016/j.humpath.2007.03.008.

DOI:10.1016/j.humpath.2007.03.008

PMID:17640554

Abstract

The patient was a 57-year-old white woman who presented with a 3.0 x 2.0-cm partially ulcerated vaginal polyp. Histology revealed a malignant mixed mullerian tumor composed of invasive squamous cell carcinoma with deeper areas of undifferentiated pleomorphic sarcoma. Invasive carcinoma had overlying high-grade vaginal intraepithelial neoplasia (VaIN III), which contained koilocytic atypia. In situ hybridization detected high-risk human papillomavirus DNA in both the carcinoma and the sarcoma components.

摘要

患者为一名57岁的白人女性，出现一个3.0×2.0厘米的部分溃疡的阴道息肉。组织学检查显示为恶性混合性苗勒管肿瘤，由浸润性鳞状细胞癌和更深层的未分化多形性肉瘤组成。浸润性癌上方有高级别阴道上皮内瘤变（VaIN III），其中含有挖空细胞异型性。原位杂交在癌和肉瘤成分中均检测到高危型人乳头瘤病毒DNA。