家族性早发性重度抑郁症患者的杏仁核和海马体体积
Amygdala and hippocampal volumes in familial early onset major depressive disorder.
作者信息
MacMaster Frank P, Mirza Yousha, Szeszko Philip R, Kmiecik Lauren E, Easter Phillip C, Taormina S Preeya, Lynch Michelle, Rose Michelle, Moore Gregory J, Rosenberg David R
机构信息
Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Children's Hospital of Michigan, Detroit, Michigan 48201, USA.
出版信息
Biol Psychiatry. 2008 Feb 15;63(4):385-90. doi: 10.1016/j.biopsych.2007.05.005. Epub 2007 Jul 20.
BACKGROUND
Abnormalities in the amygdala and hippocampus have been implicated in the pathogenesis of major depressive disorder (MDD). To our knowledge, no prior study has examined amygdala-hippocampus anatomy in pediatric patients with familial MDD (at least one first degree relative with MDD).
METHODS
Thirty-two psychotropic-naive patients with familial MDD, aged 8-21 years (12 males and 20 females), and 35 group-matched healthy participants (13 males and 22 females) underwent volumetric magnetic resonance imaging in order to evaluate hippocampal and amygdala volumes.
RESULTS
Patients with familial MDD had significantly smaller left hippocampal (p = .007, effect size [d] = .44) and right hippocampal volumes (p = .025, d = .33) than controls. No differences were noted in amygdala volumes between groups (right: p > .05, left: p > .05). No correlations between hippocampal or amygdala volumes and demographic or clinical variables were noted.
CONCLUSIONS
Reduced hippocampal volume may be suggestive of a risk factor for developing MDD.
背景
杏仁核和海马体异常与重度抑郁症（MDD）的发病机制有关。据我们所知，此前尚无研究对患有家族性MDD（至少有一位一级亲属患有MDD）的儿科患者的杏仁核 - 海马体解剖结构进行过检查。
方法
32名未服用过精神药物的8至21岁家族性MDD患者（12名男性和20名女性）以及35名年龄匹配的健康参与者（13名男性和22名女性）接受了容积磁共振成像检查，以评估海马体和杏仁核的体积。
结果
家族性MDD患者的左侧海马体体积（p = .007，效应量[d] = .44）和右侧海马体体积（p = .025，d = .33）显著小于对照组。两组之间杏仁核体积无差异（右侧：p > .05，左侧：p > .05）。未发现海马体或杏仁核体积与人口统计学或临床变量之间存在相关性。
结论
海马体体积减小可能提示是患MDD的一个风险因素。
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