Rafee Shameer, Ndukwe Ihedinachi, O'Riordan Sean, Hutchinson Michael
Department of Neurology St Vincent's University Hospital Dublin Ireland.
Mov Disord Clin Pract. 2021 Jul 8;8(6):925-931. doi: 10.1002/mdc3.13273. eCollection 2021 Aug.
The high prevalence of mood disorders in cervical dystonia, often unaddressed in botulinum toxin clinics, is a major factor in impaired quality of life. There is a clear need for a brief screening method for identifying these disorders; the Dystonia non-motor symptoms questionnaire (DNMSQuest) has been proposed as such.
We aimed to assess the practical utility of the DNMSQuest and compare it with validated rating scales for anxiety, depression and quality of life.
In 88 patients with cervical dystonia, we compared results from the DNMSQuest with mood rating scales [Beck Anxiety Inventory (BAI), Beck Depression Index (BDI-II) and Hospital Anxiety and Depression Scale (HADS)], quality of life measures [European Quality of Life (EQOL) and European Quality of Life Visual Analogue Scale (EQOLVAS)] and with assessments of dystonia severity [Cervical Dystonia Impact Profile-58 (CDIP58) and Toronto Western Rating Scale for Spasmodic Torticollis (TWSTRS)].
Using a cut off score on the DNMSQuest of 5, we noted that DNMSQuest had a sensitivity of 85% for detecting anxiety and depression using the BAI and BDI-II, and 76% and 78% for anxiety and depression respectively using the HADS. The DNMSQuest correlated strongly with BAI (ρ = 0.715), BDI-II (ρ = 0.658), HADS-Anxiety (ρ = 0.616), HADS-Depression (ρ = 0.706), EQOL (ρ = 0.653) and CDIP-58 (ρ = 0.665).
The DNMSQuest is a brief, sensitive and non-specific instrument for identifying patients that warrant further review for anxiety and depression and can easily be implemented in a neurologist-run botulinum toxin clinic.
颈部肌张力障碍患者中情绪障碍的高患病率是生活质量受损的主要因素，而肉毒毒素诊所往往未对此加以关注。显然需要一种简短的筛查方法来识别这些障碍；肌张力障碍非运动症状问卷（DNMSQuest）就是为此而提出的。
我们旨在评估DNMSQuest的实际效用，并将其与经过验证的焦虑、抑郁及生活质量评定量表进行比较。
在88例颈部肌张力障碍患者中，我们将DNMSQuest的结果与情绪评定量表[贝克焦虑量表（BAI）、贝克抑郁量表第二版（BDI-II）及医院焦虑抑郁量表（HADS）]、生活质量测量工具[欧洲生活质量量表（EQOL）和欧洲生活质量视觉模拟量表（EQOLVAS）]以及肌张力障碍严重程度评估工具[颈部肌张力障碍影响量表-58（CDIP58）和多伦多西部痉挛性斜颈评定量表（TWSTRS）]进行了比较。
使用DNMSQuest的临界值为5时，我们发现DNMSQuest使用BAI和BDI-II检测焦虑和抑郁的敏感性为85%，使用HADS检测焦虑和抑郁的敏感性分别为76%和78%。DNMSQuest与BAI（ρ = 0.715）、BDI-II（ρ = 0.658）、HADS-焦虑（ρ = 0.616）、HADS-抑郁（ρ = 0.706）、EQOL（ρ = 0.653）和CDIP-58（ρ = 0.665）密切相关。
DNMSQuest是一种简短、敏感且非特异性的工具，可用于识别需要进一步评估焦虑和抑郁情况的患者，并且可以在神经科医生管理的肉毒毒素诊所中轻松实施。
