Li Yao Yao, Ni Xiao Kang, You Ya Feng, Qing Yan Hua, Wang Pei Rong, Yao Jia Shu, Ren Ke Ming, Zhang Lei, Liu Zhi Wei, Song Tie Jun, Wang Jinhui, Zang Yu-Feng, Shen Yue di, Chen Wei
Department of Psychiatry, Hangzhou Seventh People's Hospital, Hangzhou, China.
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Front Hum Neurosci. 2021 Feb 15;15:634113. doi: 10.3389/fnhum.2021.634113. eCollection 2021.
Anxious major depressive disorder is a common subtype of major depressive disorder; however, its unique neural mechanism is not well-understood currently. Using multimodal MRI data, this study examined common and specific alterations of amygdala subregions between patients with and without anxiety. No alterations were observed in the gray matter volume or intra-region functional integration in either patient group. Compared with the controls, both patient groups showed decreased functional connectivity between the left superficial amygdala and the left putamen, and between the right superficial amygdala and the bilateral anterior cingulate cortex and medial orbitofrontal cortex, while only patients with anxiety exhibited decreased activity in the bilateral laterobasal and superficial amygdala. Moreover, the decreased activity correlated negatively with the Hamilton depression scale scores in the patients with anxiety. These findings provided insights into the pathophysiologic processes of anxious major depressive disorder and may help to develop new and effective treatment programs.
焦虑性重度抑郁症是重度抑郁症的一种常见亚型；然而，其独特的神经机制目前尚未得到充分理解。本研究利用多模态磁共振成像（MRI）数据，检查了有焦虑和无焦虑患者杏仁核亚区域的共同和特定改变。两组患者的灰质体积或区域内功能整合均未观察到改变。与对照组相比，两组患者均表现出左侧浅表杏仁核与左侧壳核之间、右侧浅表杏仁核与双侧前扣带回皮质及内侧眶额皮质之间的功能连接减少，而只有焦虑患者双侧外侧基底核和浅表杏仁核的活动减少。此外，焦虑患者的活动减少与汉密尔顿抑郁量表评分呈负相关。这些发现为焦虑性重度抑郁症的病理生理过程提供了见解，并可能有助于开发新的有效治疗方案。
