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1

Early herpes simplex virus type 1 infection is dependent on regulated Rac1/Cdc42 signalling in epithelial MDCKII cells.单纯疱疹病毒1型早期感染依赖于上皮MDCKII细胞中受调控的Rac1/Cdc42信号传导。

J Gen Virol. 2006 Dec;87(Pt 12):3483-3494. doi: 10.1099/vir.0.82231-0.

2

RhoA-GTPase facilitates entry of Kaposi's sarcoma-associated herpesvirus into adherent target cells in a Src-dependent manner.RhoA-GTP酶以一种依赖Src的方式促进卡波西肉瘤相关疱疹病毒进入贴壁靶细胞。

J Virol. 2006 Dec;80(23):11432-46. doi: 10.1128/JVI.01342-06. Epub 2006 Sep 27.

3

Beta8 integrin binds Rho GDP dissociation inhibitor-1 and activates Rac1 to inhibit mesangial cell myofibroblast differentiation.β8整合素与Rho GDP解离抑制剂-1结合并激活Rac1以抑制系膜细胞肌成纤维细胞分化。

J Biol Chem. 2006 Jul 14;281(28):19688-99. doi: 10.1074/jbc.M601110200. Epub 2006 May 11.

4

Novel, rapid assay for measuring entry of diverse enveloped viruses, including HIV and rabies.用于检测包括艾滋病毒和狂犬病病毒在内的多种包膜病毒进入的新型快速检测方法。

J Virol Methods. 2006 Aug;135(2):143-50. doi: 10.1016/j.jviromet.2006.02.011. Epub 2006 Apr 3.

5

Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death.人类免疫缺陷病毒1型（HIV-1）蛋白与细胞骨架：病毒生命与宿主细胞死亡中的伙伴

Cell Death Differ. 2005 Aug;12 Suppl 1:932-41. doi: 10.1038/sj.cdd.4401582.

6

Studies of ebola virus glycoprotein-mediated entry and fusion by using pseudotyped human immunodeficiency virus type 1 virions: involvement of cytoskeletal proteins and enhancement by tumor necrosis factor alpha.利用假型1型人类免疫缺陷病毒颗粒研究埃博拉病毒糖蛋白介导的进入和融合：细胞骨架蛋白的参与及肿瘤坏死因子α的增强作用

J Virol. 2005 Jan;79(2):918-26. doi: 10.1128/JVI.79.2.918-926.2005.

7

Viral hijacking of G-protein-coupled-receptor signalling networks.病毒对G蛋白偶联受体信号网络的劫持

Nat Rev Mol Cell Biol. 2004 Dec;5(12):998-1012. doi: 10.1038/nrm1529.

8

HIV-1 virion fusion assay: uncoating not required and no effect of Nef on fusion.HIV-1病毒体融合测定：无需脱壳且Nef对融合无影响。

Virology. 2004 Oct 10;328(1):36-44. doi: 10.1016/j.virol.2004.07.015.

9

Actin cytoskeletal reorganizations and coreceptor-mediated activation of rac during human immunodeficiency virus-induced cell fusion.人类免疫缺陷病毒诱导细胞融合过程中肌动蛋白细胞骨架重组及共受体介导的Rac激活

J Virol. 2004 Jul;78(13):7138-47. doi: 10.1128/JVI.78.13.7138-7147.2004.

10

Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.Rac GTP酶特异性小分子抑制剂的合理设计与表征

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7618-23. doi: 10.1073/pnas.0307512101. Epub 2004 May 5.

通过灵敏的HIV/SIV融合试验表征的Rac鸟苷酸交换因子抑制剂的抗病毒活性。

Antiviral activity of a Rac GEF inhibitor characterized with a sensitive HIV/SIV fusion assay.

作者信息

Pontow Suzanne, Harmon Brooke, Campbell Nancy, Ratner Lee

机构信息

Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, Box 8069, 660 S Euclid Ave, St. Louis, MO 63110, USA.

出版信息

Virology. 2007 Nov 10;368(1):1-6. doi: 10.1016/j.virol.2007.06.022. Epub 2007 Jul 19.

DOI:10.1016/j.virol.2007.06.022

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2174213/

Abstract

A virus-dependent fusion assay was utilized to examine the activity of a panel of HIV-1, -2, and SIV isolates of distinct coreceptor phenotypes. This assay allowed identification of entry inhibitors, and characterization of an antagonist of a Rac guanine nucleotide exchange factor, as an inhibitor of HIV-mediated fusion.

摘要

利用病毒依赖性融合试验检测了一组具有不同共受体表型的HIV-1、HIV-2和SIV分离株的活性。该试验能够鉴定出进入抑制剂，并将一种Rac鸟嘌呤核苷酸交换因子的拮抗剂表征为HIV介导融合的抑制剂。