Borges Adriana, Scotti Luciana V, Siqueira Daniele R, Zanini Rebeca, Amaral Fernanda do, Jurinitz Daiane F, Wassermann Guillermo F
Laboratório de Endocrinologia Experimental, Departamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Sarmento Leite, 500, CEP 90050 170, Porto Alegre, RS, Brazil.
Chemosphere. 2007 Oct;69(6):920-6. doi: 10.1016/j.chemosphere.2007.05.068. Epub 2007 Jul 20.
Jundiá (Rhamdia quelen, Quoy and Gaimard), a South American teleostean fish, was exposed to sub-lethal concentrations of cypermethrin (30% and 45% of the 48-h LC(50) value of 0.265 ppm) for 2, 4 or 8 days. Serum biochemical and hematological values and behavioral changes were studied. The 30% LC(50), 0.08 ppm, produced significant increases in Mg(2+), P, K(+), creatinine, urea, glucose, cholesterol, aspartate aminotransferase and alkaline phosphatase levels, and reduction in total proteins and triglycerides in serum. The 45% LC(50), 0.12 ppm, produced significant increase in Na(+), Mg(2+), P, K(+), creatinine, urea, glucose, cholesterol, and alkaline phosphatase, and reduction in triglycerides and alanine aminotransferase levels in serum. At this concentration, the fish showed behavior changes such as hyper-excitability, asphyxia, and widening of mouth and operculum. The hematological values remained normal, except for hemoglobin concentrations and the mean corpuscular hemoglobin concentration, which increased with exposure to 0.08 ppm and 0.12 ppm cypermethrin. Results of the present work show that biochemical analysis of serum can be useful to detect incipient cypermethrin intoxication of the shoal.
南美鲇鱼（Rhamdia quelen，Quoy和Gaimard）暴露于氯氰菊酯的亚致死浓度（分别为48小时半数致死浓度（LC50）值0.265 ppm的30%和45%）下2天、4天或8天。研究了血清生化和血液学指标以及行为变化。30% LC50（0.08 ppm）导致血清中镁离子（Mg(2+)）、磷（P）、钾离子（K(+)）、肌酐、尿素、葡萄糖、胆固醇、天冬氨酸转氨酶和碱性磷酸酶水平显著升高，总蛋白和甘油三酯水平降低。45% LC50（0.12 ppm）使血清中钠离子（Na(+)）、镁离子（Mg(2+)）、磷（P）、钾离子（K(+)）、肌酐、尿素、葡萄糖、胆固醇和碱性磷酸酶显著升高，甘油三酯和丙氨酸转氨酶水平降低。在此浓度下，鱼表现出行为变化，如过度兴奋、窒息以及嘴巴和鳃盖张大。血液学指标保持正常，但血红蛋白浓度和平均红细胞血红蛋白浓度除外，它们在暴露于0.08 ppm和0.12 ppm氯氰菊酯时升高。本研究结果表明，血清生化分析有助于检测鱼群早期的氯氰菊酯中毒情况。
