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肺腺样囊性癌:18FDG PET/CT在非典型表现管理中的应用价值

Adenoid cystic carcinoma of the lung: interest of 18FDG PET/CT in the management of an atypical presentation.

作者信息

Campistron Marion, Rouquette Isabelle, Courbon Fréderick, Chabbert Valérie, Rochaix Philippe, Prévot Grégoire, Laroumagne Sophie, Têtu Laurent, Didier Alain, Mazières Julien

机构信息

Service de Pneumologie-Allergologie, Clinique des Voies Respiratoires, Hôpital Larrey, Chemin de Pouvourville, 31059 Toulouse Cedex, France.

出版信息

Lung Cancer. 2008 Jan;59(1):133-6. doi: 10.1016/j.lungcan.2007.06.002. Epub 2007 Jul 20.

Abstract

Adenoid cystic carcinoma (ACC) is a common head and neck tumor originating from salivary glands but that can also exceptionally develop in the trachea and major bronchi. ACC is generally considered as a slow-growing, low-grade malignancy with prolonged clinical course. Metastases are very unusual and recurrences are more often local. Treatment for localized ACC is surgery. We here report for the first time a case of lung ACC with a synchronous liver metastasis proved by biopsy. Moreover, we report the interest of performing a 18FDG PET-CT as both primary tumor and liver metastasis presented an intense FDG uptake. The specificity of the liver 18FDG uptake was confirmed by Glut-1 positive immunostaining. We propose that 18FDG PET-CT should be considered in the initial staging of lung ACC in selected patients.

摘要

腺样囊性癌(ACC)是一种常见的头颈部肿瘤,起源于唾液腺,但也可罕见地发生于气管和主支气管。ACC通常被认为是一种生长缓慢、低级别恶性肿瘤,临床病程较长。转移非常少见,复发多为局部复发。局限性ACC的治疗方法是手术。我们在此首次报告一例经活检证实的伴有同步肝转移的肺ACC病例。此外,我们报告了进行18FDG PET-CT的意义,因为原发肿瘤和肝转移灶均表现出强烈的FDG摄取。通过Glut-1阳性免疫染色证实了肝脏18FDG摄取的特异性。我们建议,对于部分选定的患者,在肺ACC的初始分期中应考虑进行18FDG PET-CT检查。

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