Laurent Aurélie, Mistretta Frédéric, Bottigioli David, Dahel Karima, Goujon Catherine, Nicolas Jean François, Hennino Anca, Laurent Philippe E
Palliative Care Unit, Centre Hospitalier Lyon Sud, 69310 Pierre Bénite, France.
Vaccine. 2007 Aug 21;25(34):6423-30. doi: 10.1016/j.vaccine.2007.05.046. Epub 2007 Jun 11.
Skin thickness (epidermis-dermis) across the deltoid, suprascapular, waist and thigh as possible body sites for a new microdelivery system for intradermal (id) inoculation were evaluated using 20 MHz ultrasound echography in 205 women and 137 men aged 18-70 years, in three ethnic groups: Caucasian, Asian and Black. Mean skin thickness was 2.54 mm at the suprascapular, 2.02 mm at the deltoid, 1.91 mm at the waist and 1.55 mm at the thigh. A 1.5 mm microneedle length inserted perpendicularly to the skin surface would ensure the administration of the antigen into the dermal layer, irrespectively of subject gender, age, ethnicity and BMI. The deltoid, suprascapular and waist are the most appropriate body sites.
在205名年龄在18至70岁的女性和137名男性（分属于白种人、亚洲人和黑人三个种族群体）中，使用20兆赫超声回波描记术评估了三角肌、肩胛上、腰部和大腿处的皮肤厚度（表皮 - 真皮），这些部位可能是用于皮内（id）接种的新型微给药系统的身体部位。肩胛上处的平均皮肤厚度为2.54毫米，三角肌处为2.02毫米，腰部为1.91毫米，大腿为1.55毫米。垂直于皮肤表面插入1.5毫米的微针长度可确保将抗原注入真皮层，而与受试者的性别、年龄、种族和体重指数无关。三角肌、肩胛上和腰部是最合适的身体部位。
