Baker-Sediako Remmi Danae, Richter Benjamin, Blaicher Matthias, Thiel Michael, Hermatschweiler Martin
Nanoscribe Gmbh & Co, Hermann-von-Helmholtz-Platz 6, 76344 Eggenstein-Leopoldshafen, Germany.
Beilstein J Nanotechnol. 2023 Aug 15;14:857-864. doi: 10.3762/bjnano.14.70. eCollection 2023.
Microneedles and, subsequently, microneedle arrays are emerging miniaturized medical devices for painless transdermal drug delivery. New and improved additive manufacturing methods enable novel microneedle designs to be realized for preclinical and clinical trial assessments. However, current literature reviews suggest that industrial manufacturers and researchers have focused their efforts on one-size-fits-all designs for transdermal drug delivery, regardless of patient demographic and injection site. In this perspective article, we briefly review current microneedle designs, microfabrication methods, and industrialization strategies. We also provide an outlook where microneedles may become personalized according to a patient's demographic in order to increase drug delivery efficiency and reduce healing times for patient-centric care.
微针以及随后出现的微针阵列，正成为用于无痛透皮给药的小型化医疗设备。新型且经过改进的增材制造方法，使得能够实现用于临床前和临床试验评估的新型微针设计。然而，当前的文献综述表明，工业制造商和研究人员一直将精力集中在适用于所有情况的透皮给药设计上，而不顾及患者的人口统计学特征和注射部位。在这篇观点文章中，我们简要回顾了当前的微针设计、微制造方法和产业化策略。我们还展望了微针如何根据患者的人口统计学特征实现个性化，以便提高给药效率并减少以患者为中心的护理中的愈合时间。
