Urbano Francisco J, Leznik Elena, Llinás Rodolfo R
Department of Physiology and Neuroscience, New York University Medical Center, 550 First Avenue, New York, NY 10016, USA.
Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12554-9. doi: 10.1073/pnas.0705087104. Epub 2007 Jul 19.
Modafinil (Provigil, Modiodal), an antinarcoleptic and mood-enhancing drug, is shown here to sharpen thalamocortical activity and to increase electrical coupling between cortical interneurons and between nerve cells in the inferior olivary nucleus. After irreversible pharmacological block of connexin permeability (i.e., by using either 18beta-glycyrrhetinic derivatives or mefloquine), modafinil restored electrotonic coupling within 30 min. It was further established that this restoration is implemented through a Ca(2+)/calmodulin protein kinase II-dependent step.
莫达非尼（普罗维吉尔，莫达非尼）是一种抗发作性睡病和改善情绪的药物，在此显示它能增强丘脑皮质活动，并增加皮质中间神经元之间以及下橄榄核神经细胞之间的电耦合。在对连接蛋白通透性进行不可逆的药理学阻断后（即使用18β - 甘草次酸衍生物或甲氟喹），莫达非尼在30分钟内恢复了电紧张耦合。进一步证实这种恢复是通过一个依赖于Ca(2+)/钙调蛋白蛋白激酶II的步骤实现的。
