D'Onofrio Stasia, Mahaffey Susan, Garcia-Rill Edgar
Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, AR.
Curr Psychopharmacol. 2017;6(2):122-135. doi: 10.2174/2211556006666171024141949.
Bipolar disorder is characterized by a host of sleep-wake abnormalities that suggests that the reticular activating system (RAS) is involved in these symptoms. One of the signs of the disease is a decrease in high frequency gamma band activity, which accounts for a number of additional deficits. Bipolar disorder has also been found to overexpress neuronal calcium sensor protein 1 (NCS-1). Recent studies showed that elements in the RAS generate gamma band activity that is mediated by high threshold calcium (Ca) channels. This mini-review provides a description of recent findings on the role of Ca and Ca channels in bipolar disorder, emphasizing the involvement of arousal-related systems in the manifestation of many of the disease symptoms. This will hopefully bring attention to a much-needed area of research and provide novel avenues for therapeutic development.
双相情感障碍的特征是一系列睡眠-觉醒异常，这表明网状激活系统（RAS）参与了这些症状。该疾病的一个迹象是高频γ波段活动减少，这导致了许多其他缺陷。还发现双相情感障碍中神经元钙传感器蛋白1（NCS-1）过度表达。最近的研究表明，RAS中的元素产生由高阈值钙（Ca）通道介导的γ波段活动。这篇小型综述描述了关于Ca和Ca通道在双相情感障碍中作用的最新发现，强调了与觉醒相关的系统在许多疾病症状表现中的参与。这有望引起对一个急需研究领域的关注，并为治疗发展提供新的途径。
