暴露于野百合碱或脱氢倒千里光裂碱的大鼠组织中的肿瘤转化

Neoplastic transformation in tissues of rats exposed to monocrotaline or dehydroretronecine.

作者信息

Shumaker R C, Robertson K A, Hsu I C, Allen J R

出版信息

J Natl Cancer Inst. 1976 Apr;56(4):787-90. doi: 10.1093/jnci/56.4.787.

DOI:10.1093/jnci/56.4.787

Abstract

Male Sprague-Dawley rats received sc injections biweekly of either the pyrrolizidine alkaloid monocrotaline or its metabolite dehydroretronecine for 1 year. The animals were then observed for an additional 12 months for the induction of neoplasms. Of 60 rats that received dehydroretronecine, 39 developed rhabdomyosarcomas at the injection site, and 5 of these neoplasms metastasized. In the 60 monocrotaline-treated rats, 31 widely dispersed tumors of various cell types were recorded. The reason suggested for the variation in tissue response was that the metabolite dehydroretronecine is a proximate carcinogen, whereas monocrotaline must first be metabolized before its carcinogenic potential is realized.

摘要

雄性斯普拉格-道利大鼠每两周皮下注射一次吡咯里西啶生物碱野百合碱或其代谢产物脱氢倒千里光碱，持续1年。然后对这些动物再观察12个月，以诱导肿瘤形成。在接受脱氢倒千里光碱的60只大鼠中，39只在注射部位发生了横纹肌肉瘤，其中5只肿瘤发生了转移。在60只接受野百合碱治疗的大鼠中，记录到31个广泛分布的不同细胞类型的肿瘤。所提出的组织反应差异的原因是，代谢产物脱氢倒千里光碱是一种直接致癌物，而野百合碱在其致癌潜力得以实现之前必须先进行代谢。