某些非阿片类镇痛药商业制剂的液相色谱分析
Liquid chromatographic analysis of certain commercial formulations for non-opioid analgesics.
作者信息
Bhushan R, Gupta Deepak, Mukherjee Aparna
机构信息
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, India.
出版信息
Biomed Chromatogr. 2007 Dec;21(12):1284-90. doi: 10.1002/bmc.885.
A simple and sensitive method for separation and quantitative determination of non-opioid analgesics from pharmaceutical preparations has been developed and validated. Commercial formulations of three non-opioid analgesics, viz. paracetamol, ibuprofen and diclofenac, were chosen for present studies. These were extracted, isolated, purified and recrystallized and were characterized by melting point, lambda(max) and IR. Quantitative determination was carried out using HPLC and TLC supplemented with UV spectrophotometry.
已开发并验证了一种从药物制剂中分离和定量测定非阿片类镇痛药的简单灵敏方法。本研究选用了三种非阿片类镇痛药的市售制剂，即对乙酰氨基酚、布洛芬和双氯芬酸。对这些药物进行提取、分离、纯化和重结晶，并通过熔点、最大吸收波长（λ(max)）和红外光谱进行表征。采用高效液相色谱法（HPLC）和薄层色谱法（TLC）并辅以紫外分光光度法进行定量测定。
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