Gwosdz M, Körber A, Hillen U, Dissemond J
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Essen.
Hautarzt. 2008 May;59(5):404-8. doi: 10.1007/s00105-007-1375-0.
Sjögren syndrome is a rare chronic systemic autoimmune disease characterized by progressive dryness of the mucous membranes. There are many variable clinical manifestations. A 40-year-old woman presented with painful leg ulcers refractory to various therapies. She had a history of xerostomia and xerophthalmia for several years. Based on clinical, serologic and histopathologic findings, we diagnosed leg ulcers in primary Sjögren syndrome. Combing immunosuppressive therapy with phase-adapted modern wound-therapy resulted in a complete healing of the ulcers. In the case of clinically atypical leg ulcers, Sjögren syndrome should be considered as a rare differential diagnostic possibility.
干燥综合征是一种罕见的慢性全身性自身免疫性疾病，其特征为黏膜进行性干燥。临床表现多种多样。一名40岁女性出现腿部疼痛性溃疡，多种治疗均无效。她有口干、眼干病史数年。根据临床、血清学及组织病理学检查结果，我们诊断为原发性干燥综合征伴腿部溃疡。免疫抑制治疗与适时的现代伤口治疗相结合，使溃疡完全愈合。对于临床非典型的腿部溃疡，应考虑干燥综合征这一罕见的鉴别诊断可能。
