• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans.

作者信息

Van Laere Koen

出版信息

Eur J Nucl Med Mol Imaging. 2007 Nov;34(11):1719-26. doi: 10.1007/s00259-007-0505-3.

DOI:10.1007/s00259-007-0505-3
PMID:17643242
Abstract
摘要

相似文献

1
In vivo imaging of the endocannabinoid system: a novel window to a central modulatory mechanism in humans.内源性大麻素系统的体内成像：开启人类中枢调节机制的新窗口。
Eur J Nucl Med Mol Imaging. 2007 Nov;34(11):1719-26. doi: 10.1007/s00259-007-0505-3.
2
PET and SPECT in drug evaluation and drug design imaging inflammatory processes, tumors, and the endocannabinoid system.
Curr Pharm Des. 2008;14(31):3295-6. doi: 10.2174/138161208786549407.
3
In vivo activation of endocannabinoid system in temporal lobe epilepsy with hippocampal sclerosis.内侧颞叶癫痫伴海马硬化症中内源性大麻素系统的体内激活。
Brain. 2011 Apr;134(Pt 4):1033-40. doi: 10.1093/brain/awq385. Epub 2011 Feb 8.
4
The endocannabinoid system in the brain: from biology to therapy.
Curr Drug Targets CNS Neurol Disord. 2005 Dec;4(6):613. doi: 10.2174/156800705774933078.
5
Has PET become an important clinical tool in paediatric imaging?正电子发射断层扫描（PET）已成为儿科影像学中一项重要的临床工具了吗？
Eur J Nucl Med Mol Imaging. 2004 May;31(5):615-21. doi: 10.1007/s00259-004-1470-8. Epub 2004 Feb 5.
6
Pharmacotherapeutic targeting of the endocannabinoid signaling system: drugs for obesity and the metabolic syndrome.内源性大麻素信号系统的药物治疗靶点：用于治疗肥胖症和代谢综合征的药物
Physiol Behav. 2008 Mar 18;93(4-5):671-86. doi: 10.1016/j.physbeh.2007.11.012. Epub 2007 Nov 21.
7
Endocannabinoid control of food intake and energy balance.内源性大麻素对食物摄入和能量平衡的调控
Nat Neurosci. 2005 May;8(5):585-9. doi: 10.1038/nn1457.
8
Molecular imaging update: advances in MI of the brain.
J Nucl Med. 2007 May;48(5):24N, 29N.
9
Multiple sclerosis may disrupt endocannabinoid brain protection mechanism.多发性硬化症可能会破坏内源性大麻素对大脑的保护机制。
Proc Natl Acad Sci U S A. 2006 Apr 18;103(16):6087-8. doi: 10.1073/pnas.0601847103. Epub 2006 Apr 10.
10
Endocannabinoid mechanisms of pain modulation.内源性大麻素对疼痛的调节机制。
AAPS J. 2006 Nov 17;8(4):E693-708. doi: 10.1208/aapsj080479.

引用本文的文献

1
Association of CNR1 gene and cannabinoid 1 receptor protein in the human brain.人脑中海洛因受体 1 基因与大麻素 1 受体蛋白的关联。
J Neurosci Res. 2023 Mar;101(3):327-337. doi: 10.1002/jnr.25149. Epub 2022 Nov 28.
2
Role of Nuclear Imaging to Understand the Neural Substrates of Brain Disorders in Laboratory Animals: Current Status and Future Prospects.核成像在理解实验动物脑疾病神经基质中的作用：现状与未来展望
Front Behav Neurosci. 2020 Dec 11;14:596509. doi: 10.3389/fnbeh.2020.596509. eCollection 2020.
3
Advances in CNS Imaging Agents: Focus on PET and SPECT Tracers in Experimental and Clinical Use.

本文引用的文献

1
Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.N-{(1S,2S)-2-(3-氰基苯基)-3-[4-(2-[¹⁸F]氟乙氧基)苯基]-1-甲基丙基}-2-甲基-2-[(5-甲基吡啶-2-基)氧基]丙酰胺的发现，一种适用于临床的大麻素-1受体正电子发射断层扫描示踪剂。
J Med Chem. 2007 Jul 26;50(15):3427-30. doi: 10.1021/jm070131b. Epub 2007 Jul 3.
2
[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor.[18F]MK-9470，一种用于大麻素-1受体体内人脑正电子发射断层扫描（PET）成像的PET示踪剂。
Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9800-5. doi: 10.1073/pnas.0703472104. Epub 2007 May 29.
3
中枢神经系统成像剂的进展：聚焦于正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）示踪剂在实验和临床中的应用。
CNS Drugs. 2015 Apr;29(4):313-30. doi: 10.1007/s40263-015-0237-z.
4
The effect of anaesthesia on [(18)F]MK-9470 binding to the type 1 cannabinoid receptor in the rat brain.麻醉对 [(18)F]MK-9470 与大鼠脑内 1 型大麻素受体结合的影响。
Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1164-73. doi: 10.1007/s00259-010-1383-7. Epub 2010 Feb 25.
5
Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands.使用（18）F 标记的反向激动剂放射性配体对人和猴脑中的大麻素 CB1 受体进行成像和定量。
J Nucl Med. 2010 Jan;51(1):112-20. doi: 10.2967/jnumed.109.067074. Epub 2009 Dec 15.
6
Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors.新型高亲和力放射性碘标记配体用于脑大麻素 1 型受体成像的合成及体外放射自显影评价。
Bioorg Med Chem Lett. 2009 Nov 1;19(21):6209-12. doi: 10.1016/j.bmcl.2009.08.092. Epub 2009 Sep 3.
Regulation of PI3K/Akt/GSK-3 pathway by cannabinoids in the brain.大麻素对大脑中PI3K/Akt/GSK-3信号通路的调控
J Neurochem. 2007 Aug;102(4):1105-14. doi: 10.1111/j.1471-4159.2007.04642.x. Epub 2007 May 4.
4
[The endocannabinoid system as a novel target for the treatment of liver fibrosis].[内源性大麻素系统作为治疗肝纤维化的新靶点]
Pathol Biol (Paris). 2008 Feb;56(1):36-8. doi: 10.1016/j.patbio.2007.01.001. Epub 2007 Apr 6.
5
Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration.乙醇、海洛因和可卡因自我给药对伏隔核细胞外内源性大麻素水平的特异性改变。
J Neurosci. 2007 Apr 4;27(14):3695-702. doi: 10.1523/JNEUROSCI.4403-06.2007.
6
Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.通过神经元上的大麻素受体CB1和自身反应性T细胞上的CB2直接抑制中枢神经系统自身免疫炎症。
Nat Med. 2007 Apr;13(4):492-7. doi: 10.1038/nm1561. Epub 2007 Apr 1.
7
The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.正电子发射断层扫描（PET）放射性配体[11C]MePPEP与非人灵长类动物大脑中的大麻素CB1受体可逆结合，并具有高特异性信号。
Neuropsychopharmacology. 2008 Jan;33(2):259-69. doi: 10.1038/sj.npp.1301402. Epub 2007 Mar 28.
8
Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis.大麻素CB1和CB2受体以及脂肪酸酰胺水解酶是人类多发性硬化症中斑块细胞亚型的特异性标志物。
J Neurosci. 2007 Feb 28;27(9):2396-402. doi: 10.1523/JNEUROSCI.4814-06.2007.
9
From anecdotal evidence of cannabinoids in multiple sclerosis to emerging new therapeutical approaches.从大麻素在多发性硬化症中的轶事性证据到新兴的新治疗方法。
Mult Scler. 2007 Jan;13(1):133-4. doi: 10.1177/1352458506071303.
10
The endocannabinoid pathway in Huntington's disease: a comparison with other neurodegenerative diseases.亨廷顿舞蹈病中的内源性大麻素通路：与其他神经退行性疾病的比较
Prog Neurobiol. 2007 Apr;81(5-6):349-79. doi: 10.1016/j.pneurobio.2006.11.006. Epub 2007 Feb 2.