Wanigasuriya Kamani P, Peiris-John Roshini J, Wickremasinghe Rajitha, Hittarage Ariyasena
Department of Medicine, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.
Trans R Soc Trop Med Hyg. 2007 Oct;101(10):1013-7. doi: 10.1016/j.trstmh.2007.05.006. Epub 2007 Jul 23.
This study was conducted to determine the aetiology of chronic renal failure (CRF) in the North Central Province of Sri Lanka. Patients (n=183) with CRF of unknown aetiology were compared with controls (n=200) who had no evidence of chronic renal dysfunction. Exposure to possible risk factors were determined by an interviewer-administered questionnaire. Being a farmer (P<0.001), using pesticides (P<0.001), drinking well water (P<0.001), a family history of renal dysfunction (P=0.001), use of ayurvedic treatment (P<0.001) and a history of snake bite (P<0.001) were risk factors for CRF of unknown aetiology. Using logistic regression analysis, a family history of chronic renal disease, taking ayurvedic treatment and history of snake bite were found to be significant predictors for CRF of unknown aetiology. There is evidence to support an environmental aetiology to CRF in Sri Lanka.
本研究旨在确定斯里兰卡中北部省份慢性肾衰竭（CRF）的病因。将病因不明的慢性肾衰竭患者（n = 183）与无慢性肾功能不全证据的对照组（n = 200）进行比较。通过访员管理的问卷确定可能的危险因素暴露情况。农民身份（P<0.001）、使用杀虫剂（P<0.001）、饮用井水（P<0.001）、肾功能不全家族史（P = 0.001）、使用阿育吠陀疗法（P<0.001）和蛇咬史（P<0.001）是病因不明的慢性肾衰竭的危险因素。使用逻辑回归分析发现，慢性肾病家族史、接受阿育吠陀疗法和蛇咬史是病因不明的慢性肾衰竭的重要预测因素。有证据支持斯里兰卡慢性肾衰竭的环境病因。
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