卵巢癌中的生长因子
Growth factors in ovarian cancer.
作者信息
Owens O J, Stewart C, Leake R E
机构信息
Department of Biochemistry, Glasgow University.
出版信息
Br J Cancer. 1991 Dec;64(6):1177-81. doi: 10.1038/bjc.1991.486.
Epidermal growth factor and transforming growth factor alpha are two peptides which bind to the epidermal growth factor receptor. One hundred and seventy-four samples from 133 patients with ovarian cancer were examined for EGF and TGF alpha. EGF was detected in only 27.6% of samples while TGF alpha was present in 88.5%. The median values for TGF alpha presence were at least 10-fold greater than those of EGF. There was no statistical difference between either TGF alpha or EGF levels and degree of differentiation of the tumours. There was no statistical difference between stage three and four in relation to concentration of either peptide. Median concentration did not differ significantly among the histological sub-groups.
表皮生长因子和转化生长因子α是两种与表皮生长因子受体结合的肽。对133例卵巢癌患者的174份样本进行了表皮生长因子（EGF）和转化生长因子α（TGFα）检测。仅在27.6%的样本中检测到EGF，而88.5%的样本中存在TGFα。TGFα存在的中位数至少比EGF高10倍。TGFα或EGF水平与肿瘤分化程度之间无统计学差异。在肽的浓度方面，三期和四期之间无统计学差异。组织学亚组之间的中位数浓度无显著差异。
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