Lauterburg B, Sautter V, Herz R, Colombo J P, Roch-Ramel F, Bircher J
J Lab Clin Med. 1977 Jul;90(1):92-100.
Because of the discovery of uric acid urolithiasis in rats after end-to-side portacaval anastomosis (PCA), uric acid metabolism was studied in these animals and in appropriate controls. Hyperuricemia and hyperuricosuria were observed in all experimental rats. The fraction of purine catabolites excreted in the urine as uric acid increased from an average of 4.8% to 15.3%. If 14C-uric specifically labeled at position 6 (6-14C-ua) was infused intravenously and the exhalation of 14CO2 was used to calculate a hepatic uric acid clearance, it decreased from 2.14 to 0.97 ml/min/100 gm despite a normal content of hepatic uricase activity as measured in liver homogenates. The fraction of the filtered amount of uric acid excreted in the urine increased from an average of 11% to 30%. Increased supersaturation of the urine with uric acid after PCA may be expected to contribute to the formation of uric acid urolithiasis. This investigation defines a hepatic and renal functional defect in uric acid metabolism which occurs as a result of the PCA.
由于在大鼠端侧门腔静脉吻合术（PCA）后发现尿酸尿路结石，对这些动物以及适当的对照组进行了尿酸代谢研究。所有实验大鼠均出现高尿酸血症和高尿酸尿症。尿中作为尿酸排泄的嘌呤分解代谢产物比例从平均4.8%增至15.3%。若静脉注射在6位特异性标记的14C-尿酸（6-14C-ua），并利用呼出的14CO2计算肝脏尿酸清除率，尽管肝脏匀浆中测得的肝脏尿酸酶活性正常，但该清除率仍从2.14降至0.97 ml/min/100 gm。尿中排泄的滤过量尿酸比例从平均11%增至30%。PCA后尿中尿酸过饱和度增加可能会促使尿酸尿路结石形成。本研究确定了PCA导致的尿酸代谢中的肝脏和肾脏功能缺陷。
