Zelder O, Brümmer B, Bichler K H
Langenbecks Arch Chir. 1976;Suppl:104-7.
Significantly higher levels of uric acid in serum and urine together with increased urine volume and pH were observed in rats after portacaval end-to-side anastomosis in comparison to sham-operated and non-operated pair-fed controls. An increased supply of endogenous uric acid by reduced transformation of uric acid to allantoin and decreased uricase activity in the liver was assumed. Adaptation of enzyme activities of other metabolic pathways of the liver after PCA due to diminished blood and oxygen supply were described in previous experiments. This model seems suitable for other studies on hyperuricemia, hyperuricosuria and uric acid lithiasis.
与假手术组和未手术的配对喂养对照组相比，门腔静脉端侧吻合术后大鼠血清和尿液中的尿酸水平显著升高，同时尿量和pH值增加。推测尿酸向尿囊素的转化减少以及肝脏中尿酸酶活性降低导致内源性尿酸供应增加。先前的实验描述了门腔静脉吻合术后由于血液和氧气供应减少，肝脏其他代谢途径的酶活性发生了适应性变化。该模型似乎适用于其他关于高尿酸血症、高尿酸尿症和尿酸结石症的研究。
