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疱疹病毒蛋白:单纯疱疹病毒感染后核苷磷酸转移酶活性的诱导

Herpesvirus proteins: induction of nucleoside phosphotransferase activity after herpes simplex virus infection.

作者信息

Jamieson A T, Hay J, Subak-Sharpe J H

出版信息

J Virol. 1976 Mar;17(3):1056-9. doi: 10.1128/JVI.17.3.1056-1059.1976.

Abstract

After herpes simplex virus infection of hamster kidney cells there is an induction of nucleoside phosphotransferase activity which can utilize AMP as phosphate donor. The activity is immunologically specific for the infected cell and is induced concomitantly with the virus-coded pyrimidine deoxynucleoside kinase activity. Phosphotransferase activity is not induced in cells lacking both thymidine and deoxycytidine kinase activity.

摘要

单纯疱疹病毒感染仓鼠肾细胞后,会诱导核苷磷酸转移酶活性,该酶可利用AMP作为磷酸供体。这种活性对受感染细胞具有免疫特异性,并且与病毒编码的嘧啶脱氧核苷激酶活性同时被诱导。在缺乏胸苷激酶和脱氧胞苷激酶活性的细胞中,不会诱导磷酸转移酶活性。

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