Ogino T, Otsuka T, Takahashi M
J Virol. 1977 Mar;21(3):1232-5. doi: 10.1128/JVI.21.3.1232-1235.1977.
Deoxypyrimidine kinase (deoxythymidine [TdR] kinase and deoxycytidine kinase) activity was induced in human embryonic lung cells after infection with varicella-zoster virus (VZ virus). Increased enzyme activity was also produced by using cell-associated virus as inoculum instead of cell-free virus. Anti-VZ virus serum inhibited both the appearance of cytopathic effect and the induction of enzyme activity. The induced TdR kinase activity was more thermostable than that induced by herpes simplex virus type 1. Also, the TdR kinase activity of VZ virus-infected cells was inhibited by dTTP less than in mock-infected cells and more than in herpes simplex virus type 1-infected cells.
人胚肺细胞感染水痘-带状疱疹病毒（VZ病毒）后，脱氧嘧啶激酶（脱氧胸苷激酶和脱氧胞苷激酶）活性被诱导。用细胞相关病毒而非无细胞病毒作为接种物也能产生增加的酶活性。抗VZ病毒血清可抑制细胞病变效应的出现和酶活性的诱导。诱导的胸苷激酶活性比单纯疱疹病毒1型诱导的更耐热。此外，VZ病毒感染细胞的胸苷激酶活性受脱氧胸苷三磷酸（dTTP）的抑制程度低于 mock 感染细胞，高于单纯疱疹病毒1型感染细胞。
