Chen Bo-Shiun, Roche Katherine W
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Neuropharmacology. 2007 Sep;53(3):362-8. doi: 10.1016/j.neuropharm.2007.05.018. Epub 2007 Jun 2.
N-methyl-D-aspartate (NMDA) receptors are critical for neuronal development and synaptic plasticity. The molecular mechanisms underlying the synaptic localization and functional regulation of NMDA receptors have been the subject of extensive studies. In particular, phosphorylation has emerged as a fundamental mechanism that regulates NMDA receptor trafficking and can alter the channel properties of NMDA receptors. Here we summarize recent advances in the characterization of NMDA receptor phosphorylation, emphasizing subunit-specific phosphorylation, which differentially controls the trafficking and surface expression of NMDA receptors.
N-甲基-D-天冬氨酸(NMDA)受体对神经元发育和突触可塑性至关重要。NMDA受体突触定位和功能调节的分子机制一直是广泛研究的主题。特别是,磷酸化已成为调节NMDA受体转运并可改变NMDA受体通道特性的基本机制。在这里,我们总结了NMDA受体磷酸化特征的最新进展,重点强调亚基特异性磷酸化,它对NMDA受体的转运和表面表达有不同的控制作用。