NMDA受体的磷酸化调节
Regulation of NMDA receptors by phosphorylation.
作者信息
Chen Bo-Shiun, Roche Katherine W
机构信息
National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Neuropharmacology. 2007 Sep;53(3):362-8. doi: 10.1016/j.neuropharm.2007.05.018. Epub 2007 Jun 2.
Abstract
N-methyl-D-aspartate (NMDA) receptors are critical for neuronal development and synaptic plasticity. The molecular mechanisms underlying the synaptic localization and functional regulation of NMDA receptors have been the subject of extensive studies. In particular, phosphorylation has emerged as a fundamental mechanism that regulates NMDA receptor trafficking and can alter the channel properties of NMDA receptors. Here we summarize recent advances in the characterization of NMDA receptor phosphorylation, emphasizing subunit-specific phosphorylation, which differentially controls the trafficking and surface expression of NMDA receptors.
摘要
N-甲基-D-天冬氨酸（NMDA）受体对神经元发育和突触可塑性至关重要。NMDA受体突触定位和功能调节的分子机制一直是广泛研究的主题。特别是，磷酸化已成为调节NMDA受体转运并可改变NMDA受体通道特性的基本机制。在这里，我们总结了NMDA受体磷酸化特征的最新进展，重点强调亚基特异性磷酸化，它对NMDA受体的转运和表面表达有不同的控制作用。
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本文引用的文献
1
Modulation of D2R-NR2B interactions in response to cocaine.
Neuron. 2006 Dec 7;52(5):897-909. doi: 10.1016/j.neuron.2006.10.011.
2
NMDA receptor surface mobility depends on NR2A-2B subunits.
Proc Natl Acad Sci U S A. 2006 Dec 5;103(49):18769-74. doi: 10.1073/pnas.0605238103. Epub 2006 Nov 21.
3
Synaptic plasticity and phosphorylation.
Pharmacol Ther. 2006 Dec;112(3):810-32. doi: 10.1016/j.pharmthera.2006.06.003. Epub 2006 Aug 14.
4
Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation.
J Biol Chem. 2006 Jun 16;281(24):16583-90. doi: 10.1074/jbc.M513029200. Epub 2006 Apr 10.
5
Protein kinase A regulates calcium permeability of NMDA receptors.
Nat Neurosci. 2006 Apr;9(4):501-10. doi: 10.1038/nn1664. Epub 2006 Mar 12.
6
NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.
J Neurosci. 2006 Jan 11;26(2):708-15. doi: 10.1523/JNEUROSCI.4409-05.2006.
7
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia.
Nature. 2006 Feb 23;439(7079):988-92. doi: 10.1038/nature04474. Epub 2005 Dec 21.
8
NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury.
Nature. 2005 Dec 22;438(7071):1167-71. doi: 10.1038/nature04301.
9
NMDA receptors are expressed in oligodendrocytes and activated in ischaemia.
Nature. 2005 Dec 22;438(7071):1162-6. doi: 10.1038/nature04302.
10
Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons.
J Neurophysiol. 2006 Mar;95(3):1727-34. doi: 10.1152/jn.00771.2005. Epub 2005 Nov 30.
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