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自由基对模型用于解释磁场对 NMDA 受体活性的影响。

Radical pair model for magnetic field effects on NMDA receptor activity.

机构信息

Department of Physics, Indian Institute of Science Education and Research (IISER), Tirupati, Tirupati, Andhra Pradesh, 517507, India.

Department of Physics and Astronomy, University of Calgary, Calgary, AB, T2N 1N4, Canada.

出版信息

Sci Rep. 2024 Feb 13;14(1):3628. doi: 10.1038/s41598-024-54343-y.


DOI:10.1038/s41598-024-54343-y
PMID:38351304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10864372/
Abstract

The N-methyl-D-aspartate receptor is a prominent player in brain development and functioning. Perturbations to its functioning through external stimuli like magnetic fields can potentially affect the brain in numerous ways. Various studies have shown that magnetic fields of varying strengths affect these receptors. We propose that the radical pair mechanism, a quantum mechanical process, could explain some of these field effects. Radicals of the form [Formula: see text], where R is a protein residue that can be Serine or Tyrosine, are considered for this study. The variation in the singlet fractional yield of the radical pairs, as a function of magnetic field strength, is calculated to understand how the magnetic field affects the products of the radical pair reactions. Based on the results, the radical pair mechanism is a likely candidate for explaining the magnetic field effects observed on the receptor activity. The model predicts changes in the behaviour of the system as magnetic field strength is varied and also predicts certain isotope effects. The results further suggest that similar effects on radical pairs could be a plausible explanation for various magnetic field effects within the brain.

摘要

N-甲基-D-天冬氨酸受体是大脑发育和功能的重要参与者。通过磁场等外部刺激对其功能的干扰可能会以多种方式影响大脑。各种研究表明,不同强度的磁场会影响这些受体。我们提出自由基对机制,一种量子力学过程,可以解释其中的一些场效应。为此研究考虑了形式为 [Formula: see text] 的自由基,其中 R 是可以是丝氨酸或酪氨酸的蛋白质残基。自由基对的单线态分数产率随磁场强度的变化被计算出来,以了解磁场如何影响自由基对反应的产物。基于结果,自由基对机制是解释观察到的受体活性的磁场效应的一个可能的候选者。该模型预测了系统行为随磁场强度变化的变化,并且还预测了某些同位素效应。结果还表明,类似的自由基对效应可能是大脑内各种磁场效应的合理解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bc/10864372/eb8cc6b65b48/41598_2024_54343_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bc/10864372/ebae1b75377c/41598_2024_54343_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bc/10864372/eb8cc6b65b48/41598_2024_54343_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bc/10864372/ebae1b75377c/41598_2024_54343_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69bc/10864372/eb8cc6b65b48/41598_2024_54343_Fig2_HTML.jpg

相似文献

[1]
Radical pair model for magnetic field effects on NMDA receptor activity.

Sci Rep. 2024-2-13

[2]
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[3]
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[4]
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[7]
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[9]
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[10]
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本文引用的文献

[1]
Statistical Amplification of the Effects of Weak Magnetic Fields in Cellular Translation.

Cells. 2023-2-24

[2]
Evidence of the static magnetic field effects on bone-related diseases and bone cells.

Prog Biophys Mol Biol. 2023-1

[3]
Radical pairs may explain reactive oxygen species-mediated effects of hypomagnetic field on neurogenesis.

PLoS Comput Biol. 2022-6

[4]
Transcranial Magnetic Stimulation as a Diagnostic and Therapeutic Tool in Various Types of Dementia.

J Clin Med. 2021-6-28

[5]
The Analgesic Effects of Static Magnetic Fields.

Bioelectromagnetics. 2021-2

[6]
Insights in the biology of extremely low-frequency magnetic fields exposure on human health.

Mol Biol Rep. 2020-7

[7]
Transcranial static magnetic stimulation -From bench to bedside and beyond.

Neurosci Res. 2020-7

[8]
Extremely low frequency magnetic field induces human neuronal differentiation through NMDA receptor activation.

J Neural Transm (Vienna). 2019-7-17

[9]
The Role of NMDA Receptors in Alzheimer's Disease.

Front Neurosci. 2019-2-8

[10]
Long-distance navigation and magnetoreception in migratory animals.

Nature. 2018-6-6

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