石杉属植物中的石杉碱甲——民族药理学综述

Huperzine A from Huperzia species--an ethnopharmacolgical review.

作者信息

Ma Xiaoqiang, Tan Changheng, Zhu Dayuan, Gang David R, Xiao Peigen

机构信息

State Key Laboratory of Drug Research, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China.

出版信息

J Ethnopharmacol. 2007 Aug 15;113(1):15-34. doi: 10.1016/j.jep.2007.05.030. Epub 2007 Jun 2.

DOI:10.1016/j.jep.2007.05.030

PMID:17644292

Abstract

Huperzine A (HupA), isolated originally from a traditional Chinese medicine Qiang Ceng Ta, whole plant of Huperzia serrata (Thunb. ex Murray) Trev., a member of the Huperziaceae family, has attracted intense attention since its marked anticholinesterase activity was discovered by Chinese scientists. Several members of the Huperziaceae (Huperzia and Phlegmariurus species) have been used as medicines in China for contusions, strains, swellings, schizophrenia, myasthenia gravis and organophosphate poisoning. HupA has been marketed in China as a new drug for Alzheimer's disease (AD) treatment and its derivative ZT-1 is being developed as anti-AD new drug candidate both in China and in Europe. A review of the chemistry, bioactivities, toxicology, clinical trials and natural resources of HupA source plants is presented.

摘要

石杉碱甲（HupA）最初是从一种传统中药千层塔中分离出来的，千层塔是石杉科植物蛇足石杉（Huperzia serrata (Thunb. ex Murray) Trev.）的全草。自从中国科学家发现其显著的抗胆碱酯酶活性以来，它就引起了广泛关注。石杉科的几种植物（石杉属和马尾杉属物种）在中国已被用作治疗跌打损伤、扭伤、肿胀、精神分裂症、重症肌无力和有机磷中毒的药物。石杉碱甲在中国已作为治疗阿尔茨海默病（AD）的新药上市，其衍生物ZT - 1在中国和欧洲都正在作为抗AD新药候选物进行研发。本文对石杉碱甲源植物的化学、生物活性、毒理学、临床试验及自然资源进行了综述。