Patocka J
Purkynĕ Military Medical Academy, Hradec Králové.
Acta Medica (Hradec Kralove). 1998;41(4):155-7.
Huperzine A, alkaloid from the Chinese herbal medicine Qian Ceng Ta, which is prepared from the moss Huperzia serrata, has been used in China for centuries to treat fever and inflammation. Huperzine A is a strong inhibitor of cholinesterases with high selectivity to acetylcholinesterase and in China is developed as therapeutic against Alzheimer's disease. May be that huperzine A will be better than other centrally active anticholinesterases in treating this neurodegenerative disorder. Huperzine A appears to have additional pharmacological properties that make it an attractive candidate therapy for clinical trials.
石杉碱甲是一种从中国草药千层塔中提取的生物碱，千层塔由蛇足石杉这种苔藓植物制备而成，在中国已被用于治疗发热和炎症数百年。石杉碱甲是一种强效胆碱酯酶抑制剂，对乙酰胆碱酯酶具有高度选择性，在中国已被开发用于治疗阿尔茨海默病。在治疗这种神经退行性疾病方面，石杉碱甲可能比其他中枢活性抗胆碱酯酶药物效果更好。石杉碱甲似乎还具有其他药理特性，这使其成为临床试验中颇具吸引力的候选治疗药物。
