Tomobe Koji, Fujii Hajime, Sun Buxiang, Nishioka Hiroshi, Aruoma Okezie I
Amino Up Chemical Company, 363-32 Shin-ei, Kiyota-ku, Sapporo, 004-0839, Japan.
Biomed Pharmacother. 2007 Aug;61(7):427-34. doi: 10.1016/j.biopha.2007.05.007. Epub 2007 Jun 12.
Oligonol is produced from the oligomerization of polyphenols (typically proanthocyanidin from a variety of fruits such as lychees, grapes, apples, persimmons, etc.) and contains catechin-type monomers and oligomers of proanthocyanidins. The ability of Oligonol to affect infection-dependent eye inflammation, locomotion and longevity in senescence-accelerated prone mice (SAMP8) (a model of senescence acceleration and geriatric disorders with increased oxidative stress and neuronal deficit) was investigated. Oligonol (60mg/kg) significantly modulated the extent of inflammation scores in the eye of SAMP8 mice. Examination of the mice indicated infection with mouse hepatitis virus and pinworm (Syphacia obvelata) in both males and females and with the intestinal protozoa (trichomonad) in males. A comparison of the two groups (using log-rank test) and the difference in the mean life span between groups (using Student's t-test) indicated significant differences in survival (p=0.043) and the mean life span (p=0.033) in male SAMP8 mice. Oligonol increased the mean life span and this was statistically significant. In the open-field locomotive test, the 7-week-old SAMP8 mice crossed more than 40 partitioned lines in 1min. At 48-week-old control untreated male SAMP8 crossed 2 lines. The Oligonol-treated 48-week-old male SAMP8 mice crossed 17 lines however. The improved locomotive activity was statistically significant even after 36weeks in the Oligonol-treated male SAMP8 but this was not the case throughout the time course of the study in the Oligonol-treated female SAMP8. Thus Oligonol treatment to SAMP8 mice modulated the severity of infection-dependent inflammation, prolonged life-span and significantly improved locomotive activity indicating potential benefit to aging-associated diseases such as Alzheimer's or Parkinson's diseases. This presents potential for further research to define infection-dependent inflammation associated with degenerative conditions and the molecular mechanism of dietary antioxidant protection.
低聚多酚是由多酚（通常是来自荔枝、葡萄、苹果、柿子等多种水果的原花青素）寡聚化产生的，含有儿茶素型单体和原花青素低聚物。研究了低聚多酚对衰老加速易感小鼠（SAMP8）（一种衰老加速和老年疾病模型，具有氧化应激增加和神经元缺陷）中感染依赖性眼部炎症、运动能力和寿命的影响。低聚多酚（60mg/kg）显著调节了SAMP8小鼠眼部炎症评分的程度。对小鼠的检查表明，雄性和雌性小鼠均感染了小鼠肝炎病毒和蛲虫（Obvelata管圆线虫），雄性小鼠还感染了肠道原生动物（滴虫）。两组比较（采用对数秩检验）以及两组平均寿命差异（采用学生t检验）表明，雄性SAMP8小鼠在生存率（p=0.043）和平均寿命（p=0.033）方面存在显著差异。低聚多酚延长了平均寿命，且具有统计学意义。在旷场运动试验中，7周龄的SAMP8小鼠在1分钟内穿过了40多条分隔线。48周龄未治疗的对照雄性SAMP8小鼠穿过了2条线。然而，经低聚多酚处理的48周龄雄性SAMP8小鼠穿过了17条线。经低聚多酚处理的雄性SAMP8小鼠在36周后运动活性的改善仍具有统计学意义，但在整个研究过程中，经低聚多酚处理的雌性SAMP8小鼠并非如此。因此，对SAMP8小鼠进行低聚多酚处理可调节感染依赖性炎症的严重程度，延长寿命，并显著改善运动活性，这表明对阿尔茨海默病或帕金森病等与衰老相关的疾病具有潜在益处。这为进一步研究确定与退行性疾病相关的感染依赖性炎症以及膳食抗氧化保护的分子机制提供了潜力。
