Rochu D, Crespeau H, Fine J M
Laboratoire d'Immunochimie Analytique, Institut National de Transfusion Sanguine, Paris, France.
Biochimie. 1991 May;73(5):617-9. doi: 10.1016/0300-9084(91)90032-v.
Until recently, the characterization of genetic variants of human serum albumin was performed by electrophoretic typing prior to the determination of their amino acid substitutions. We describe a procedure using isoelectric focusing in the presence of urea for the analysis of the genetic variation of albumin. This procedure allowed a clear distinction of a new variant, previously found to be identical with albumin Sondrio according to its relative electrophoretic mobilities at 3 pHs. This new variant, the third rare albumin allotype identified in the Ile-de-France region, was called albumin Paris 2.
直到最近，人类血清白蛋白基因变异体的表征是在确定其氨基酸替换之前通过电泳分型进行的。我们描述了一种在尿素存在下使用等电聚焦分析白蛋白基因变异的方法。该方法能够清晰区分一种新变异体，根据其在3种pH值下的相对电泳迁移率，该变异体之前被发现与白蛋白桑德里奥相同。这种新变异体是在法兰西岛地区鉴定出的第三种罕见白蛋白异型，被称为白蛋白巴黎2型。
