Meyer E L, Marcus C, Waldenlind E
Department of Clinical Neuroscience K8, Division of Neurology at Karolinska Institutet, Stockholm, Sweden.
Cephalalgia. 2007 Aug;27(8):912-9. doi: 10.1111/j.1468-2982.2007.01366.x. Epub 2007 Jul 23.
We have previously shown decreased, nocturnal lipolysis in both phases of cluster headache (CH). Lipolysis is stimulated by noradrenaline (NA), growth hormone (GH) and cortisol, and inhibited by insulin, hormones which are directly or indirectly regulated by the hypothalamus. Our aim was to investigate the nocturnal secretion of NA, GH, cortisol and insulin in nine CH patients in remission and 10 healthy controls. Nocturnal venous blood samples were collected in hourly intervals for analysis of NA, cortisol and insulin and in 30-min intervals for GH. We found a reduced increase in GH between 24.00 h and 01.00 h (anova, P < 0.05) in CH patients. Nocturnal secretion of NA, cortisol and insulin did not differ significantly between the groups. The altered nocturnal GH pattern that was seen in CH patients in remission might in part explain the altered nocturnal lipolysis previously found and further indicate a permanent hypothalamic disturbance in CH.
我们之前已经表明，丛集性头痛（CH）两个阶段的夜间脂肪分解均减少。脂肪分解受去甲肾上腺素（NA）、生长激素（GH）和皮质醇刺激，并受胰岛素抑制，这些激素直接或间接受下丘脑调节。我们的目的是研究9例缓解期CH患者和10例健康对照者夜间NA、GH、皮质醇和胰岛素的分泌情况。每小时采集一次夜间静脉血样以分析NA、皮质醇和胰岛素，每30分钟采集一次以分析GH。我们发现，CH患者在24:00至01:00之间GH的升高减少（方差分析，P<0.05）。两组之间夜间NA、皮质醇和胰岛素的分泌没有显著差异。缓解期CH患者出现的夜间GH模式改变可能部分解释了之前发现的夜间脂肪分解改变，并进一步表明CH存在永久性下丘脑功能紊乱。
