印楝油挥发性成分的抗生育活性。

Antifertility activity of volatile fraction of neem oil.

作者信息

Riar S S, Devakumar C, Sawhney R C, Ilavazhagan G, Bardhan J, Kain A K, Thomas P, Singh R, Singh B, Parshad R

机构信息

Defence Institute of Physiology and Allied Sciences, Delhi Cantt, India.

出版信息

Contraception. 1991 Sep;44(3):319-26. doi: 10.1016/0010-7824(91)90021-7.

DOI:10.1016/0010-7824(91)90021-7

PMID:1764946

Abstract

NIM-76, the odorous and volatile fraction of neem oil, was investigated for its antifertility activity in vivo in rats, rabbits and rhesus monkeys. The drug is effective when applied before coitus but not so when applied during post-coital stages. It, therefore, appears to act mainly by its spermicidal effect. No alteration in the estradiol (E2) and progesterone (P) values was observed after the application of the drug in monkeys.

摘要

印楝油的有气味和挥发性部分NIM - 76在大鼠、兔子和恒河猴体内进行了抗生育活性研究。该药物在性交前应用时有效，但在性交后阶段应用则无效。因此，它似乎主要通过其杀精作用发挥功效。在给猴子应用该药物后，未观察到雌二醇（E2）和孕酮（P）值有变化。