[脂质、瘦素及瘦素受体基因多态性与乳腺癌风险的关联]

[Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer].

作者信息

Han Cun-zhi, Shi Jing, Du Li-li, Jing Jie-xian, Zhao Xian-wen, Tian Bao-guo, Tian Fu-guo, Liu Xiu-ying, Zhang Zhong-shu, Zhang Jin

机构信息

Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2007 Feb;28(2):136-40.

PMID:17649682

Abstract

OBJECTIVE

To evaluate the association between serum level of leptin and leptin receptor gene (LEPR) polymorphism and patients with breast cancer.

METHODS

LEPR G1n223Arg polymorphism was detected by polymerase chain reaction-restriction fragment length polymorphism in 94 patients with breast cancer and 128 healthy controls. The level of leptin were analyzed by enzyme linked immunosorbent assay.

RESULTS

In univariate regression analyses, we found serum level of leptin and LEPR Gin223Arg genotype polymorphism were significantly higrer than those of the controls (P < 0.05-0.001, respectively). Through multivariable analyses, we found that increased risk estimates for breast cancer were among those with leptin level (OR = 1.53, 95% CI: 1.13-2.07, P = 0.006), LEPR Gin223Arg genotype (OR = 4.87, 95%CI:1.30-18.22, P = 0.019), WHR (OR = 3.68, 95% CI: 1.34-10.11, P = 0.011).

CONCLUSION

Results from this study suggested that LEPR Gln233Agr polymorphism, the elevated WHR and serum level of leptin might be correlated with increased risk of breast cancer.

摘要

目的

评估血清瘦素水平及瘦素受体基因（LEPR）多态性与乳腺癌患者之间的关联。

方法

采用聚合酶链反应-限制性片段长度多态性方法检测94例乳腺癌患者和128例健康对照者的LEPR G1n223Arg多态性。采用酶联免疫吸附测定法分析瘦素水平。

结果

在单因素回归分析中，我们发现乳腺癌患者的血清瘦素水平和LEPR Gin223Arg基因型多态性显著高于对照组（分别为P < 0.05 - 0.001）。通过多因素分析，我们发现乳腺癌风险增加的估计值存在于瘦素水平较高者（OR = 1.53，95%CI：1.13 - 2.07，P = 0.006）、LEPR Gin223Arg基因型者（OR = 4.87，95%CI：1.30 - 18.22，P = 0.019）、腰臀比（WHR）较高者（OR = 3.68，95%CI：1.34 - 10.11，P = 0.011）中。