Department of Oncology, Kunshan People's Hospital-Jiangsu University, No. 91 Qianjin Road, Kunshan, Jiangsu, China.
Breast Cancer Res Treat. 2012 Nov;136(1):231-9. doi: 10.1007/s10549-012-2228-9. Epub 2012 Sep 15.
Many epidemiological studies have found that leptin correlates to body fat extent and breast cancer. Leptin exerts its physiological action through the leptin receptor (LEPR). However, published data on the association between LEPR alleles and breast cancer occurrence have led to in contradictory results. A total of 10 studies were identified to the meta-analysis, including 4,644 cases and 5,485 controls for LEPR rs1137101 polymorphism, 5 studies with 2,759 cases and 4,464 controls for rs1137100 polymorphism, and 2 studies for rs8051542, rs8051542, and rs8051542 polymorphisms. The pooled odds ratios (OR) with 95 % confidence intervals (CI) for breast cancer risk associated with LEPR genotypes were estimated. Elevated breast cancer risk was associated with LEPR rs1137101 polymorphism when all studies were pooled in the meta-analysis (allele contrast model: OR = 0.71, 95 % CI = 0.551-0.997). In the stratified analysis by ethnicity, significantly increased risks were also found among Asians for allele contrast model (OR 0.414, 95 % CI 0.312-0.550) and dominant model (OR 0.537, 95 % CI 0.370-0.781); for Africans, significantly increased risks were also found for allele contrast model (OR 0.716, 95 % CI 0.595-0.861), homozygote codominant (OR 0.537, 95 % CI 0.370-0.781) and dominant model (OR 1.595, 95 % CI 1.207-2.108). And significantly elevated breast cancer risk was associated with LEPR rs1137100 polymorphism for allele contrast (OR = 0.666, 95 % CI = 0.603-0.720) and homozygote codominant models (OR = 0.344, 95 % CI = 0.282-0.421). For LEPR rs8179183, rs4655537, and rs3762274 polymorphisms, no significant associations were detected in all comparison models. This pooled analysis suggested that rs1137101 and rs1137100 polymorphisms were significantly correlated with breast cancer risk and the A allele of LEPR rs1137101 variant and the G allele of LEPR rs1137100 variant were low-penetrant risk factors for developing breast cancer. Further, no significant associations existed between LEPR rs8179183, rs4655537, and rs3762274 polymorphisms and risk of breast cancer.
许多流行病学研究发现瘦素与体脂肪程度和乳腺癌有关。瘦素通过瘦素受体（LEPR）发挥其生理作用。然而，已发表的关于 LEPR 等位基因与乳腺癌发生之间关联的研究数据导致结果相互矛盾。共有 10 项研究被纳入荟萃分析，包括 LEPR rs1137101 多态性的 4644 例病例和 5485 例对照，rs1137100 多态性的 5 项研究有 2759 例病例和 4464 例对照，rs8051542、rs8051542 和 rs8051542 多态性的 2 项研究。使用 95%置信区间（CI）估计与 LEPR 基因型相关的乳腺癌风险的合并优势比（OR）。当所有研究都纳入荟萃分析时，LEPR rs1137101 多态性与乳腺癌风险升高相关（等位基因对比模型：OR=0.71，95%CI=0.551-0.997）。按种族进行分层分析，在亚洲人中，等位基因对比模型（OR 0.414，95%CI 0.312-0.550）和显性模型（OR 0.537，95%CI 0.370-0.781）也发现显著增加的风险；对于非洲人，在等位基因对比模型（OR 0.716，95%CI 0.595-0.861）、纯合子共显性（OR 0.537，95%CI 0.370-0.781）和显性模型（OR 1.595，95%CI 1.207-2.108）中也发现显著增加的风险。LEPR rs1137100 多态性的等位基因对比（OR=0.666，95%CI=0.603-0.720）和纯合子共显性模型（OR=0.344，95%CI=0.282-0.421）与乳腺癌风险显著升高相关。对于 LEPR rs8179183、rs4655537 和 rs3762274 多态性，在所有比较模型中均未检测到显著关联。这项荟萃分析表明，rs1137101 和 rs1137100 多态性与乳腺癌风险显著相关，LEPR rs1137101 变体的 A 等位基因和 LEPR rs1137100 变体的 G 等位基因是乳腺癌发生的低外显度风险因素。此外，LEPR rs8179183、rs4655537 和 rs3762274 多态性与乳腺癌风险之间不存在显著关联。
