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Fine-tuning the amphiphilicity: a crucial parameter in the design of potent alpha-phenyl-N-tert-butylnitrone analogues.

作者信息

Durand Grégory, Poeggeler Burkhard, Böker Jutta, Raynal Simon, Polidori Ange, Pappolla Miguel A, Hardeland Rüdiger, Pucci Bernard

机构信息

Laboratoire de Chimie BioOrganique et des Systèmes Moléculaires Vectoriels, Faculté des Sciences, Université d'Avignon et des Pays de Vaucluse, 33 Rue Louis Pasteur, 84000 Avignon, France.

出版信息

J Med Chem. 2007 Aug 23;50(17):3976-9. doi: 10.1021/jm0706968. Epub 2007 Jul 25.

DOI:10.1021/jm0706968
PMID:17649989
Abstract

A new series of hydrophilic, lipophilic, and amphiphilic alpha-phenyl-N-tert-butylnitrone (PBN) derivatives were synthesized to explore the relationship between their hydrophilic-lipophilic properties and antioxidant potency. Very potent protective effects of amphiphilic lactobionamide and tris(hydroxymethyl)aminomethane PBN derivatives were observed in mitochondrial preparations, in cell cultures, and in rotifers exposed to unspecific and mitochondria targeted oxidotoxins.

摘要

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