Santa Maria Peter L, Atlas Marcus D, Ghassemifar Reza
Ear Sciences Centre, School of Surgery and Pathology, University of Western Australia, Perth, Western Australia, Australia.
Wound Repair Regen. 2007 Jul-Aug;15(4):450-8. doi: 10.1111/j.1524-475X.2007.00251.x.
Developments in the treatment of chronic tympanic membrane perforation have been hindered by the lack of an ideal animal model. It is not appropriate to test such treatments on acute perforations as the majority of these heal spontaneously. An ideal animal model would be one that most closely resembles the human clinical situation. It should be inexpensive, readily available, and easy to create. There have been a number of attempts to create a chronic tympanic membrane perforation model with limited success. All published attempts at chronic tympanic membrane perforations have been reviewed and the limitations of each model are discussed. A number of areas for research exist for further developing a chronic tympanic membrane perforation model. These areas include a perforation model in the presence of bacteria and eustachian tube dysfunction. Understanding the molecular and genetic mechanisms of chronic otitis media and potential treatments will also be useful.
理想动物模型的缺失阻碍了慢性鼓膜穿孔治疗方法的发展。在急性穿孔上测试此类治疗方法并不合适，因为大多数急性穿孔会自愈。理想的动物模型应与人类临床情况最为相似。它应价格低廉、易于获取且易于构建。人们曾多次尝试创建慢性鼓膜穿孔模型，但成效有限。本文回顾了所有已发表的慢性鼓膜穿孔模型构建尝试，并讨论了每种模型的局限性。为进一步开发慢性鼓膜穿孔模型，仍有许多研究领域有待探索。这些领域包括存在细菌和咽鼓管功能障碍情况下的穿孔模型。了解慢性中耳炎的分子和遗传机制以及潜在治疗方法也将有所助益。
