Zhang Zhixin, Liu Peng, Xue Xinmiao, Zhang Zhiyu, Wang Li, Jiang Yvke, Zhang Chi, Zhou Hanwen, Lv Shuhan, Shen Weidong, Yang Shiming, Wang Fangyuan
Senior Department of Otolaryngology Head and Neck Surgery, the Sixth Medical Center of Chinese PLA General Hospital, Chinese PLA Medical School, Beijing 100853, China.
State Key Laboratory of Hearing and Balance Science, Beijing 100853, China.
iScience. 2025 Jan 3;28(2):111705. doi: 10.1016/j.isci.2024.111705. eCollection 2025 Feb 21.
Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role in clinical practice. This blood derivative, enriched with platelet components, has shown great potential for promoting tissue repair and regeneration. Its wide range of applications and the presence of anti-inflammatory and growth-promoting factors make it a valuable tool in the field of biomedicine. The exploration of PRP in clinical settings has been gaining momentum. Despite its cost-effectiveness, safety, and therapeutic efficacy, the widespread clinical adoption of PRP has been hindered by the absence of consistent preparation standards and standardized treatment protocols. This article provides a comprehensive analysis of the clinical uses, physiological roles, molecular mechanisms, and preparation techniques of PRP in biomedicine. The aim is to offer a thorough understanding of the potential applications and benefits of PRP in medical practice.
21世纪生物医学取得了重大进展，富血小板血浆（PRP）在临床实践中发挥着关键作用。这种富含血小板成分的血液衍生物在促进组织修复和再生方面显示出巨大潜力。其广泛的应用以及抗炎和促生长因子的存在使其成为生物医学领域的一种有价值的工具。PRP在临床环境中的探索一直在加速。尽管PRP具有成本效益、安全性和治疗效果，但由于缺乏一致的制备标准和标准化的治疗方案，其在临床上的广泛应用受到了阻碍。本文对PRP在生物医学中的临床用途、生理作用、分子机制和制备技术进行了全面分析。目的是全面了解PRP在医学实践中的潜在应用和益处。
