一种合生元奶制品对人体肠道生态系统的影响。

Effects of a synbiotic milk product on human intestinal ecosystem.

作者信息

Casiraghi M C, Canzi E, Zanchi R, Donati E, Villa L

机构信息

Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, Milan, Italy.

出版信息

J Appl Microbiol. 2007 Aug;103(2):499-506. doi: 10.1111/j.1365-2672.2006.03273.x.

DOI:10.1111/j.1365-2672.2006.03273.x

PMID:17650211

Abstract

AIMS

To investigate the effect of prolonged consumption of a synbiotic milk (Synbiotic) containing Lactobacillus acidophilus (strain 74-2, 10(7) CFU ml(-1)), Bifidobacterium lactis (strain 420, 10(7) CFU ml(-1)) and 2% inulin on colonic ecosystem in healthy humans.

METHODS AND RESULTS

A group of 26 healthy subjects, aged 22-47 years, participated in a 6-week placebo-controlled dietary intervention study. After a 2-week baseline period, in which all volunteers consumed 500 ml day(-1) of 2% skimmed milk (Placebo), the study was designed as a randomized, double-blind, two-armed parallel study in which 4-week consumption of 500 ml day portions of Synbiotic or Placebo were compared. Faecal microbial counts, pH, l-lactic acid and bile acid concentrations were assessed before and after the intervention. Synbiotic consumption significantly decreased faecal dry weight (P < 0.01) and l-lactic acid (P < 0.05) concentration, while significantly increased faecal bifidobacteria (P < 0.05) and lactobacilli (P < 0.01) counts.

CONCLUSION

The tested synbiotic milk showed its synbiotic nature by enhancing the growth of bifidobacteria and lactobacilli.

SIGNIFICANCE AND IMPACT OF THE STUDY

Scientific support to functional effect of a synbiotic milk.

摘要

目的

研究长期饮用含有嗜酸乳杆菌（菌株74 - 2，10⁷CFU/ml）、双歧杆菌（菌株420，10⁷CFU/ml）和2%菊粉的合生元牛奶（Synbiotic）对健康人结肠生态系统的影响。

方法与结果

一组26名年龄在22 - 47岁的健康受试者参与了一项为期6周的安慰剂对照饮食干预研究。在为期2周的基线期内，所有志愿者每天饮用500毫升2%的脱脂牛奶（安慰剂），之后该研究设计为随机、双盲、双臂平行研究，比较4周内每天饮用500毫升合生元牛奶或安慰剂的情况。在干预前后评估粪便微生物计数、pH值、l - 乳酸和胆汁酸浓度。饮用合生元牛奶显著降低了粪便干重（P < 0.01）和l - 乳酸浓度（P < 0.05），同时显著增加了粪便双歧杆菌（P < 0.05）和乳酸杆菌（P < 0.01）计数。