Casiraghi M C, Canzi E, Zanchi R, Donati E, Villa L
Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, Milan, Italy.
J Appl Microbiol. 2007 Aug;103(2):499-506. doi: 10.1111/j.1365-2672.2006.03273.x.
To investigate the effect of prolonged consumption of a synbiotic milk (Synbiotic) containing Lactobacillus acidophilus (strain 74-2, 10(7) CFU ml(-1)), Bifidobacterium lactis (strain 420, 10(7) CFU ml(-1)) and 2% inulin on colonic ecosystem in healthy humans.
A group of 26 healthy subjects, aged 22-47 years, participated in a 6-week placebo-controlled dietary intervention study. After a 2-week baseline period, in which all volunteers consumed 500 ml day(-1) of 2% skimmed milk (Placebo), the study was designed as a randomized, double-blind, two-armed parallel study in which 4-week consumption of 500 ml day portions of Synbiotic or Placebo were compared. Faecal microbial counts, pH, l-lactic acid and bile acid concentrations were assessed before and after the intervention. Synbiotic consumption significantly decreased faecal dry weight (P < 0.01) and l-lactic acid (P < 0.05) concentration, while significantly increased faecal bifidobacteria (P < 0.05) and lactobacilli (P < 0.01) counts.
The tested synbiotic milk showed its synbiotic nature by enhancing the growth of bifidobacteria and lactobacilli.
Scientific support to functional effect of a synbiotic milk.
研究长期饮用含有嗜酸乳杆菌（菌株74 - 2，10⁷CFU/ml）、双歧杆菌（菌株420，10⁷CFU/ml）和2%菊粉的合生元牛奶（Synbiotic）对健康人结肠生态系统的影响。
一组26名年龄在22 - 47岁的健康受试者参与了一项为期6周的安慰剂对照饮食干预研究。在为期2周的基线期内，所有志愿者每天饮用500毫升2%的脱脂牛奶（安慰剂），之后该研究设计为随机、双盲、双臂平行研究，比较4周内每天饮用500毫升合生元牛奶或安慰剂的情况。在干预前后评估粪便微生物计数、pH值、l - 乳酸和胆汁酸浓度。饮用合生元牛奶显著降低了粪便干重（P < 0.01）和l - 乳酸浓度（P < 0.05），同时显著增加了粪便双歧杆菌（P < 0.05）和乳酸杆菌（P < 0.01）计数。
经测试的合生元牛奶通过促进双歧杆菌和乳酸杆菌的生长显示出其合生元特性。
为合生元牛奶的功能效果提供科学支持。
