van Winkel R, Myin-Germeys I, De Hert M, Delespaul P, Peuskens J, van Os J
University Psychiatric Center Catholic University Leuven, Leuvensesteenweg, Kortenberg, Belgium.
Acta Psychiatr Scand. 2007 Aug;116(2):119-24. doi: 10.1111/j.1600-0447.2007.01014.x.
The presence of a prospective association between cognition and functional outcome in first episode patients with schizophrenia is much debated.
Associations between Intelligence Quotient (IQ) measures and functional outcome were assessed at the first hospitalization and after 10 years follow-up.
Functional outcome was associated with estimated premorbid IQ and IQ at 10-year follow-up, but not with IQ assessed at first hospitalization.
The presence of a prospective as well as a cross-sectional relationship of the global cognitive measure IQ with 10-year functional outcome could be established. However, assessing associations between cognitive measures assessed at first hospitalization and subsequent functional outcome, can give inconclusive results due to non-uniform intellectual deterioration from premorbid level in the period preceding the first hospitalization.
