Wang Mei-hao, Zhu Yi-hong, Li Jian-ce, Weng Xu-chu
Department of Radiology, First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China.
Zhonghua Yi Xue Za Zhi. 2007 Apr 10;87(14):971-4.
To investigate the roles the different functional activation areas in whole human brain related to movement play during motor preparation (CUE) and execution (GO).
Event-related functional MRI technique was used on 12 right-handed healthy subjects to record the brain activation in a manner of delayed sequential finger movement. Activation maps and time-signal intensity curves were generated.
Bilateral anterior parts of supplementary motor area (Pre-SMA), bilateral posterior parietal cortex (PPC), and bilateral anterior premotor cortex (PMC) were strongly activated during the preparation period, while bilateral SMA proper, and contralateral primary motor cortex (M1) were strongly activated during the execution period, Cerebellar cortex was activated during both periods. The time-signal intensity curves based on single voxel indicated that above-mentioned brain areas were activated during both periods to different degrees; however, the characteristics of distribution in every area were different.
The brain areas related to movement are activated differently during preparation period and execution period, areas close to M1 participate in the motor execution process mainly, and the areas away from M1 are concerned with motor preparation process chiefly.
探讨全脑不同功能激活区在运动准备（提示）和执行（执行指令）过程中与运动相关的作用。
对12名右利手健康受试者采用事件相关功能磁共振成像技术，以延迟顺序手指运动的方式记录脑激活情况。生成激活图和时间信号强度曲线。
在准备期，双侧辅助运动区前部（前辅助运动区）、双侧顶叶后皮质（顶叶后皮质）和双侧运动前区前部（运动前区前部）强烈激活；而在执行期，双侧狭义辅助运动区和对侧初级运动皮质（M1）强烈激活，小脑皮质在两个时期均被激活。基于单像素的时间信号强度曲线表明，上述脑区在两个时期均有不同程度的激活，但各区域的分布特征不同。
与运动相关的脑区在准备期和执行期的激活方式不同，靠近M1的区域主要参与运动执行过程，远离M1的区域主要与运动准备过程有关。
