Zhang Qin, Ding Hui
Guizhou Second People's Hospital, Guiyang, Guizhou, China.
Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, China.
Front Neurol. 2024 Sep 24;15:1439939. doi: 10.3389/fneur.2024.1439939. eCollection 2024.
Resting-state functional magnetic resonance imaging (rs-fMRI) reveals diverse neural activity patterns in cervical spondylosis (CS) patients. However, the reported results are inconsistent. Therefore, our objective was to conduct a meta-analysis to synthesize the findings from existing rs-fMRI studies and identify consistent patterns of neural brain activity alterations in patients with CS.
A systematic search was conducted across PubMed, Web of Knowledge, Embase, Google Scholar, and CNKI for rs-fMRI studies that compared CS patients with healthy controls (HCs), up to January 28, 2024. Significant cluster coordinates were extracted for comprehensive analysis.
We included 16 studies involving 554 CS patients and 488 HCs. CS patients demonstrated decreased brain function in the right superior temporal gyrus and left postcentral gyrus, and increased function in the left superior frontal gyrus. Jackknife sensitivity analysis validated the robustness of these findings, and Egger's test confirmed the absence of significant publication bias ( > 0.05). Meta-regression showed no significant impact of age or disease duration differences on the results.
This meta-analysis confirms consistent alterations in specific brain regions in CS patients, highlighting the potential of rs-fMRI to refine diagnostic and therapeutic strategies.
https://www.crd.york.ac.uk/prospero/, identifier CRD42024496263.
静息态功能磁共振成像（rs-fMRI）揭示了颈椎病（CS）患者多样的神经活动模式。然而，已报道的结果并不一致。因此，我们的目的是进行一项荟萃分析，以综合现有rs-fMRI研究的结果，并确定CS患者神经脑活动改变的一致模式。
截至2024年1月28日，在PubMed、Web of Knowledge、Embase、谷歌学术和中国知网中对比较CS患者与健康对照（HCs）的rs-fMRI研究进行了系统检索。提取显著的簇坐标进行综合分析。
我们纳入了16项研究，涉及554例CS患者和488例HCs。CS患者右侧颞上回和左侧中央后回的脑功能降低，左侧额上回的功能增强。留一法敏感性分析验证了这些发现的稳健性，Egger检验证实不存在显著的发表偏倚（>0.05）。荟萃回归显示年龄或病程差异对结果无显著影响。
这项荟萃分析证实了CS患者特定脑区的一致改变，突出了rs-fMRI在优化诊断和治疗策略方面的潜力。
