Cooper Rose A
Department of Applied Sciences, Centre for Biomedical Sciences, Cardiff School of Health Sciences, University of Wales Institute Cardiff, Western Avenue, Cardiff CF5 2YB, UK.
Int Wound J. 2007 Jun;4(2):124-37. doi: 10.1111/j.1742-481X.2007.00314.x.
Iodine is an antiseptic that has been used in wound care for more than 150 years. Traditional formulations of iodine had serious limitations that were reduced in later products. Much has been written about iodine and opinions on its clinical efficacy are divided. There have been reviews of the chemical properties of iodine, its antimicrobial activity, human physiology, cytotoxicity and its clinical effectiveness, but few have addressed all these aspects. With the recent development of iodine-containing wound care products and the continued publication of laboratory and clinical studies, it seems timely to reassess the evidence relating to the effectiveness of iodine for treating wounds. This literature review attempts to provide an appropriate chemical and physiological background of the characteristics of iodine in order to provide a sound basis for understanding the available microbiological and clinical data. It will show that understanding the factors that contribute to the activity and potential cytotoxicity of iodine are important in evaluating the clinical evidence. Although definitive studies are needed, the sustained delivery of low doses of free iodine offers the potential to inhibit a broad range of microbial species without selecting for resistant strains or inducing cytotoxic effects.
碘是一种防腐剂，已在伤口护理中使用了150多年。传统的碘制剂存在严重局限性，不过在后来的产品中这些局限性有所减少。关于碘的著述颇多，人们对其临床疗效的看法存在分歧。已有关于碘的化学性质、抗菌活性、人体生理学、细胞毒性及其临床有效性的综述，但很少有涉及所有这些方面的。随着含碘伤口护理产品的近期发展以及实验室和临床研究的不断发表，重新评估碘治疗伤口有效性的相关证据似乎恰逢其时。这篇文献综述试图提供碘特性的适当化学和生理学背景，以便为理解现有的微生物学和临床数据提供坚实基础。它将表明，了解导致碘活性和潜在细胞毒性的因素对于评估临床证据很重要。尽管需要确定性研究，但持续递送低剂量的游离碘有可能抑制广泛的微生物种类，而不会选择耐药菌株或诱导细胞毒性作用。
