Xu Liang, Wang Yaxing, Yang Hua, Jonas Jost B
Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital University of Medical Science, Beijing, China.
Am J Ophthalmol. 2007 Oct;144(4):541-6. doi: 10.1016/j.ajo.2007.05.038. Epub 2007 Jul 25.
To determine in a population-based study whether parapapillary atrophy is associated with glaucoma.
Population-based cross-sectional study.
The Beijing Eye Study included 4,439 of 5,324 subjects invited to participate (response rate, 83.4%). Mean age was 56.2 +/- 10.6 years (range, 40 to 101 years). Color optic disk photographs (30 degrees) were examined morphometrically. Parapapillary atrophy was divided into alpha and beta zones. Glaucomatous optic nerve atrophy was defined by a glaucomatous optic nerve head appearance.
After excluding highly myopic eyes, data from 4,003 (90.2%) subjects entered the statistical analysis. Glaucomatous optic nerve damage was detected in 93 (2.3%) subjects. The beta zone of parapapillary atrophy as a whole and measured separately in four disk sectors was significantly larger and occurred significantly more frequently in the glaucomatous group than in the nonglaucomatous group (beta zone total area, 1.21 +/- 1.92 mm2 vs 0.32 +/- 0.99 mm2; P < .001). In multiple regression analysis, area of beta zone was significantly associated with age (P < .001), myopic refractive error (P < .001), and presence of glaucomatous optic nerve damage (P < .001), with no significant difference between chronic open-angle glaucoma (n = 72) and chronic angle-closure glaucoma (n = 21; beta zone area, 1.20 +/- 0.39 mm2 vs 1.19 +/- 0.46 mm2; P = .69).
In a population-based setting, the beta zone of parapapillary atrophy is significantly larger and occurs more frequently in glaucomatous eyes than in normal eyes of Chinese adults, with no marked difference between chronic open-angle glaucoma and primary angle-closure glaucoma.
在一项基于人群的研究中确定视盘旁萎缩是否与青光眼相关。
基于人群的横断面研究。
北京眼病研究纳入了受邀参与的5324名受试者中的4439名（应答率为83.4%）。平均年龄为56.2±10.6岁（范围40至101岁）。对视盘彩色照片（30度）进行形态学测量。视盘旁萎缩分为α区和β区。青光眼性视神经萎缩由青光眼性视盘外观定义。
排除高度近视眼后，4003名（90.2%）受试者的数据进入统计分析。在93名（2.3%）受试者中检测到青光眼性视神经损害。视盘旁萎缩的β区整体以及在四个视盘象限分别测量时，青光眼组均显著大于非青光眼组，且出现频率显著更高（β区总面积，1.21±1.92平方毫米对0.32±0.99平方毫米；P<.001）。在多元回归分析中，β区面积与年龄（P<.001）、近视屈光不正（P<.001）和青光眼性视神经损害的存在（P<.001）显著相关，慢性开角型青光眼（n = 72）和慢性闭角型青光眼（n = 21）之间无显著差异（β区面积，1.20±0.39平方毫米对1.19±0.46平方毫米；P =.69）。
在基于人群的研究中，中国成年人青光眼眼中视盘旁萎缩的β区显著大于正常眼，且出现频率更高，慢性开角型青光眼和原发性闭角型青光眼之间无明显差异。
