Taylor Kimberly M, LaBonne Carole
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208, USA.
Curr Opin Genet Dev. 2007 Aug;17(4):326-31. doi: 10.1016/j.gde.2007.05.012. Epub 2007 Jul 24.
Substantial progress has been made in defining the regulatory factors involved in generating multipotent neural crest cells at the neural plate border of vertebrate embryos, controlling the onset of their migratory behavior, and directing their differentiation into one of a diverse array of derivatives. Growing evidence suggests that these factors function as a complex network, in some cases displaying overlapping functions and cross-regulatory interactions. Mechanisms are emerging for how some of these regulatory components are controlled post-translationally and the extent to which their activities are conserved across species.
在确定参与在脊椎动物胚胎神经板边界产生多能神经嵴细胞、控制其迁移行为的起始以及引导其分化为多种衍生物之一的调控因子方面已经取得了重大进展。越来越多的证据表明，这些因子作为一个复杂的网络发挥作用，在某些情况下表现出重叠的功能和交叉调控相互作用。关于这些调控成分中的一些如何在翻译后受到控制以及它们的活性在物种间保守的程度，相关机制正在浮现。
