Sox5 是 BMP R-Smads 的 DNA 结合辅因子，在早期外胚层的模式形成过程中指导靶特异性。
Sox5 Is a DNA-binding cofactor for BMP R-Smads that directs target specificity during patterning of the early ectoderm.
机构信息
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, IL 60208, USA.
出版信息
Dev Cell. 2014 Nov 10;31(3):374-382. doi: 10.1016/j.devcel.2014.10.003.
The SoxD factor, Sox5, is expressed in ectodermal cells at times and places where BMP signaling is active, including the cells of the animal hemisphere at blastula stages and the neural plate border and neural crest at neurula stages. Sox5 is required for proper ectoderm development, and deficient embryos display patterning defects characteristic of perturbations of BMP signaling, including loss of neural crest and epidermis and expansion of the neural plate. We show that Sox5 is essential for activation of BMP target genes in embryos and explants, that it physically interacts with BMP R-Smads, and that it is essential for recruitment of Smad1/4 to BMP regulatory elements. Our findings identify Sox5 as the long-sought DNA-binding partner for BMP R-Smads essential to plasticity and pattern in the early ectoderm.
SoxD 因子 Sox5 在 BMP 信号活跃的外胚层细胞中表达，包括囊胚阶段的动物半球细胞和神经板边缘和神经嵴。Sox5 是外胚层发育所必需的，而缺陷胚胎表现出与 BMP 信号扰动特征一致的模式缺陷，包括神经嵴和表皮的丧失以及神经板的扩张。我们表明 Sox5 对于胚胎和外植体中 BMP 靶基因的激活是必需的，它与 BMP R-Smads 物理相互作用，并且对于 Smad1/4 募集到 BMP 调节元件是必需的。我们的发现确定 Sox5 是早期外胚层可塑性和模式所必需的 BMP R-Smads 的长期寻求的 DNA 结合伴侣。
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