Botton J, Heude B, Andre P, Bresson J L, Ducimetiere P, Charles M A
Inserm, U780, IFR69, 16, avenue Paul-Vaillant-Couturier, 94807 Villejuif, France; Faculté de médecine, université Paris-Sud, IFR69, 63, rue Gabriel-Péri, 94276 Le Kremlin-Bicêtre, France.
Diabetes Metab. 2007 Nov;33(5):354-9. doi: 10.1016/j.diabet.2007.03.008. Epub 2007 Jul 24.
Elevated gamma-glutamyltransferase (GGT) is positively associated with severity of obesity in obese children and with increased BMI and waist circumference in general populations of adults. We aimed to study the relationships between GGT and anthropometric parameters in a general population of children.
This cross-sectional study was conducted in 219 boys and 214 girls included in the Fleurbaix Laventie Ville Santé II study. Weight, height, four skinfolds and waist circumference were measured. We compared the means of GGT activity according to gender and Tanner stage, and according to overweight status (IOTF definition) and quartiles of anthropometric parameters. We then calculated partial Pearson correlations by gender between GGT and anthropometric parameters taking age and Tanner stage into account.
GGT activity was higher in boys than in girls as soon as puberty started (P<0.001). The higher difference was observed for Tanner stage III (GGT=10.2 UI/L, CI95% of mean (9.5, 11.1) vs. 7.8 UI/L (7.2, 8.4)). Anthropometric parameters were significantly associated with GGT, particularly waist circumference (r=0.28 in boys; r=0.24 in girls). After an additional adjustment for sum of skinfolds, this correlation disappeared in boys (r=0.06), and was still significant in girls (r=0.19).
In a general population of children, overweight and abdominal fat distribution were associated with increased GGT. As some studies have shown that GGT could predict the metabolic syndrome in children and type 2 diabetes in adults, the modest elevation of GGT observed in overweight children may be of pathophysiological importance in the long term.
在肥胖儿童中，γ-谷氨酰转移酶（GGT）升高与肥胖严重程度呈正相关，在成年普通人群中与体重指数（BMI）增加和腰围增大相关。我们旨在研究普通儿童人群中GGT与人体测量学参数之间的关系。
本横断面研究纳入了弗勒拜-拉文蒂-维勒桑特二世研究中的219名男孩和214名女孩。测量了体重、身高、四处皮褶厚度和腰围。我们根据性别和坦纳分期，以及根据超重状态（国际肥胖工作组定义）和人体测量学参数四分位数比较了GGT活性的均值。然后考虑年龄和坦纳分期，按性别计算GGT与人体测量学参数之间的偏皮尔逊相关性。
青春期一开始，男孩的GGT活性就高于女孩（P<0.001）。在坦纳III期观察到的差异更大（GGT = 10.2国际单位/升，均值的95%置信区间（9.5，11.1），而女孩为7.8国际单位/升（7.2，8.4））。人体测量学参数与GGT显著相关，尤其是腰围（男孩r = 0.28；女孩r = 0.24）。在对皮褶厚度总和进行额外调整后，这种相关性在男孩中消失（r = 0.06），而在女孩中仍然显著（r = 0.19）。
在普通儿童人群中，超重和腹部脂肪分布与GGT升高有关。由于一些研究表明GGT可预测儿童代谢综合征和成人2型糖尿病，超重儿童中观察到的GGT适度升高从长期来看可能具有病理生理学重要性。
